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Mood Disorders

開催日 2014/9/12
時間 14:00 - 15:00
会場 Poster / Exhibition(Event Hall B)

Examination of the change of IDO expression in the mouse brain under inflammatory condition

  • P2-336
  • 石田 雄介 / Yusuke Ishida:1 中村 雪子Yukiko Nakamura 近藤 誠Makoto Kondo 島田 昌一Shoichi Shimada 
  • 1:大阪大院・医・1解剖 / Dept Anatomy I, Univ of Osaka, Osaka, Japan 

It has been reported that the depression is related to inflammation. By the way, the serotonin is produced from tryptophan, while indolamine 2,3 dioxygenase (IDO) is the enzyme which converts tryptophan into kynurenine. Although the local existence in the normal brain of IDO is still discussed, it has been reported that expression of IDO rises to several times in brain when inflammation happens. When IDO increase under the inflammatory condition, tryptophan would be converted into kynurenine, and production of serotonin would be decreased. Therefore, we supposed that depression would happen as a result of serotonin decrease. However, it is still unknown that which part of the brain expression of IDO increase in under the inflammatory condition. Moreover, in addition to IDO1, a novel isoform indolamine 2,3 dioxygenase 2 (IDO2) had been identified. We think that it is necessary to examine these expression in detail at first. Now, we examine the expression of IDO1 and IDO2 in the mouse brain which given lipopolysaccharide (LPS) or polyinosinic:polycytidylic acid (poly I:C, a toll-like receptor-3 agonist), and caused inflammation, using in situ hybridization and northern blot analysis. In this conference, we show the results and discuss whether IDO expression increase in the mouse brain under inflammatory condition.

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