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Autonomic Nervous System

開催日 2014/9/11
時間 16:00 - 17:00
会場 Poster / Exhibition(Event Hall B)

Centrally administered bombesin activates hemoglobin-containing pre-sympathetic neurons in rat hypothalamic paraventricular nucleus

  • P1-194
  • 田中 健二朗 / Kenjiro Tanaka:1 清水 孝洋 / Takahiro Shimizu:2 齊藤 源顕 / Motoaki Saito:2 由利 和也 / Kazunari Yuri:1 
  • 1:高知大・医・解剖 / Dept Neurobiol Anat, Kochi Med Sch, Kochi Univ, Japan 2:高知大・医・薬理 / Dept Pharmacol, Kochi Med Sch, Kochi Univ, Japan 

A hemoglobin α-chain-derived peptide RVD-hemopressin is reported as a ligand for cannabinoid CB1 receptors. We previously showed that RVD-hemopressin inhibited centrally administered bombesin (a stress-related peptide)-induced secretion of adrenal catecholamines (adrenaline and noradrenaline) in the rat, suggesting an inhibitory role of brain cannabinoid system in the sympatho-adrenomedullary outflow. In this study, pre-sympathetic spinally projecting neurons of the rat hypothalamic paraventricular nucleus (PVN), which are thought to regulate the adrenal response, were labeled with a fluorescent retrograde tracer. Then, we examined the immunoreactivity of hemoglobin α-chain or RVD-hemopressin with neuronal activation marker Fos in the fluorescently labeled pre-sympathetic neurons following the intracerebroventricular administration of bombesin. The bombesin induced Fos immunoreactivity in pre-sympathetic PVN neurons with hemoglobin α-chain immunoreactivity. RVD-hemopressin-like immunoreactivity was also detected in pre-sympathetic neurons of the PVN. These findings implicate the involvement of hemoglobin α-chain and RVD-hemopressin in modulating sympatho-adrenomedullary outflow.

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