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Reproduction, Feeding and Metabolic Regulation

開催日 2014/9/12
時間 10:00 - 11:00
会場 Room J(313+314)
Chairperson(s) 功刀 浩 / Hiroshi Kunugi (独立行政法人国立精神・神経医療研究センター 神経研究所 / Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Japan)
上田 陽一 / Yoichi Ueta (産業医科大学医学部 第3生理学 / Department of Physiology, School of Medicine, University of Occupational and Environmental Health, Japan)

高脂肪餌食によるsensorimotor gatingの悪化 -マウスでの検討-
High fat diet-induced deficiency of prepulse inhibition in mice

  • O2-J-2-3
  • 若林 千里 / Chisato Wakabayashi:1 沼川 忠広 / Tadahiro Numakawa:1 大島 淑子 / Yoshiko Ooshima:1 服部 功太郎 / Kotaro Hattori:1 功刀 浩 / Hiroshi Kunugi:1 
  • 1:(独)国立精神・神経医療研究センター 神経研究所 / National Institute of Neuroscience, NCNP, Japan 

Although high fat diet (HFD) is well known to induce obesity, detailed knowledge of its effect on mental illness has not yet been fully elucidated. We found that the HFD induced the disruption of prepulse inhibition (PPI) of acoustic startle response, a measurement of sensorimotor gating that is deficient in schizophrenia, after 10 weeks of HFD fed in 5 week-old male mice. The spontaneous locomotor activity was unchanged by the HFD compared to normal diet (ND) in the open-field test. The disruption of PPI was sustained even 4-week after the HFD finished. Western blot analysis revealed that glycogen synthase kinase (GSK)3α/β phosphorylation was increased while the amount of GSK3α/β protein did not change in the striatum of HFD mice. In addition, GSK3α/β protein expression was decreased in the prefrontal cortex of HFD mice. HFD also induced PPI disruption for dopamine D2 receptor KO mice. Although it was not significant, the D2 receptor KO mice showed lower PPI compared with the WT littermates. This is the first evidence that HFD significantly affects both phosphorylation and protein expression of GSK3α/β in the striatum and prefrontal cortex, respectively. These findings are consistent, at least in part, with previous postmortem studies in schizophrenia, suggesting that HFD mice may be a good animal model for schizophrenia.

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