演題詳細
Poster
学習・長期記憶
Learning and Long-term Memory
| 開催日 | 2014/9/11 |
|---|---|
| 時間 | 11:00 - 12:00 |
| 会場 | Poster / Exhibition（Event Hall B） |
運動課題学習中の一次運動野第2/3および第5a層での集団および個々の細胞における神経活動変化
Dynamics of cortical ensemble and single-neuron activities in layers 2/3 and 5a of the primary motor cortex during learning of a motor task
- P1-271
- 正水 芳人 / Yoshito Masamizu:1,2 田中 R 康裕 / Yasuhiro R Tanaka:1,2 田中 H 康代 / Yasuyo H Tanaka:1,2 平 理一郎 / Riichiro Hira:1,2 大久保 文貴 / Fuki Ohkubo:1,2,3 喜多村 和郎 / Kazuo Kitamura:4,5 礒村 宜和 / Yoshikazu Isomura:6 岡田 尚巳 / Takashi Okada:7 松崎 政紀 / Masanori Matsuzaki:1,2,3
- 1:自然科学研究機構・基礎生物学研究所・光脳回路研究部門 / Div Brain Circuits, National Institute for Basic Biology, Aichi, Japan 2:科学技術振興機構・戦略的創造研究推進事業 / JST, CREST, Saitama, Japan 3:総合研究大学院大学 / The Graduate University of Advanced Studies, Kanagawa, Japan 4:東京大学・神経生理学分野 / Dept Neurophysiol, Univ of Tokyo, Tokyo, Japan 5:科学技術振興機構・戦略的創造研究推進事業 / JST, PREST, Saitama, Japan 6:玉川大学・脳科学研究所 / Brain Science Institute, Tamagawa University, Tokyo, Japan 7:日本医科大学・生化学・分子生物学(分子遺伝学)講座 / Department of Biochemistry and Molecular Biology, Nippon Medical School, Tokyo, Japan
The primary motor cortex possesses two intermediate layers upstream of the motor-output layer(layer 5b): Layer 2/3 and layer 5a. Although repetitive training often improves motor performance and movement coding by primary motor cortex neuronal ensembles, it is unclear how neuronal activities in layer 2/3 and layer 5a are reorganized during learning of a motor task. We conducted two-photon calcium imaging in the mouse primary motor cortex while mice practiced a self-initiated lever-pull task. In layer 2/3, the accuracy of neuronal ensemble prediction of lever trajectory remained globally unchanged with a subset of individual neurons retaining high prediction accuracy throughout the training period. However, in layer 5a, the ensemble prediction steadily improved and a subset of individual neurons evolved to contribute substantially to ensemble prediction in the late stage of learning.