• Top page
  • Timetable
  • Per session
  • Per presentation
  • How to
  • Meeting Planner



Stem Cells, Neuronal and Glial Production/Differentiation

開催日 2014/9/11
時間 11:00 - 12:00
会場 Poster / Exhibition(Event Hall B)

Malnutrition of n-6 and n-3 polyunsaturated fatty acids disturbs neocortical development

  • P1-075
  • 酒寄 信幸 / Nobuyuki Sakayori:1,2 大隅 典子 / Noriko Osumi:1 
  • 1:東北大院・医・発生発達 / Div. of Dev. Neurosci., Grad. Sch. of Med., Tohoku Univ. 2:日本学術振興会 特別研究員 / JSPS Research Fellow 

Polyunsaturated fatty acids (PUFAs) are important nutrients because they compose biological structures and produce biologically active substances. Especially, n-6 and n-3 PUFAs are the dominant PUFAs in the brain and are involved in brain functions. It is known that not only the amount but also the ratio of n-6 and n-3 PUFAs are important for various biological functions explained by their mutual competition for metabolism, transport and acylation into cell membranes. In the modern society, intake of n-6 PUFAs has dramatically increased mainly due to the intake of seed oils. Actually, the ratio of n-6/n-3 PUFAs in the diet has steadily increased to 10-25 in industrialized countries, although appropriate n-6/n-3 PUFA ratio in nutrition is considered to be1-4. Here, we investigated effects of n-6 excess/n-3 deficient diet on neocortical development. We fed control or n-6 excess/n-3 deficient diet to pregnant mice and examined neocortical multilayer formation of their pups at postnatal day 10. Pups in the n-6 excess/n-3 deficient condition exhibited decrease in thickness of both deep and upper layers of the neocortex. We further observed impaired neuronal differentiation of neural stem cells from excess/n-3 deficient embryos. We further performed mediator lipidomics analyses and found that epoxy metabolites from n-6 PUFAs and n-3 PUFAs were increased and decreased, respectively, in the fetal brain. These results demonstrate that maternal intake of n-6 excess/n-3 deficient diet during gestation and lactation periods alters embryonic cortical neurogenesis possibly through epoxy metabolites.

Copyright © Neuroscience2014. All Right Reserved.