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Working Memory and Executive Function

開催日 2014/9/13
時間 11:00 - 12:00
会場 Poster / Exhibition(Event Hall B)

Infralimbic cortical neuronal activities are related to inhibition of impulsive behavior

  • P3-235
  • 木村 生 / Iku Kimura:1,2 大村 優 / Yu Ohmura:3 泉 剛 / Takeshi Izumi:3 松島 俊也 / Toshiya Matsushima:4 吉田 隆行 / Takayuki Yoshida:3 吉岡 充弘 / Mitsuhiro Yoshioka:3 
  • 1:慶應大・医・精神神経科学 / Dept Neuropsychiatry, Keio Univ, Tokyo, Japan 2:日本学術振興会特別研究員RPD / JSPS Research Fellow, Tokyo, Japan 3:北海道大・院医・神経薬理 / Dept Neuropharmacol, Hokkaido Univ, Sapporo, Japan 4:北海道大院・理・生物科学 / Dept Biol Sci, Hokkaido Univ, Sapporo, Japan 

Disruption of controlling impulsivity is an intolerable symptom observed in various psychiatric disorders and could be a risk factor for drug addiction, criminal involvement, and suicide. To elucidate the neurophysiological basis of behavioral inhibition, we recorded single-unit activity in the infralimbic cortex (IL), where is a ventral part of the medial prefrontal cortex, of the rat performing the 3-choice serial reaction time task (3-CSRTT). This task requires the rat to inhibit nose poke responding until a light stimulus is presented briefly in one of three holes. Above 60% (38/56) of isolated IL units were linked to behavioral inhibition. Inactivation of the IL with muscimol (0.1 g/side) disrupted behavioral inhibition in the 3-CSRTT. Furthermore, we employed a 2-choice task (2-CT) which is a more accurate behavioral task in terms of the control of movement. In this task, the rat is required to keep pushing a front panel with its nose until a light stimulus is presented briefly in one of two holes. We first evaluated the pharmacological validity of the 2-CT using nicotine (0.2 mg/kg) and milnacipran (10 mg/kg) that were previously characterized to disrupt and enhance behavioral inhibition in the 3-CSRTT, respectively. Above 30% (14/44) of recorded IL units were linked to behavioral inhibitions in the 2-CT. Most of them showed a transient decline of firing rate immediately before release of behavioral inhibition. These findings suggest that the rat IL plays an important role in inhibition of impulsive behavior.

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