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Trophic Factors

開催日 2014/9/12
時間 18:10 - 19:10
会場 Room J(313+314)
Chairperson(s) 小島 正己 / Masami Kojima (独立行政法人産業技術総合研究所 健康工学研究部門 バイオインターフェース研究グループ / Biointerface Research Group, Health Research Institute (HRI), National Institute of Advanced Industrial Science and Technology (AIST), )
篠田 陽 / Yo Shinoda (東京理科大学理工学部 応用生物科学科 / Deparment of Applied Biological Science, Faculty of Science and Technology, Tokyo University of Science, Japan)

Decreased release of neurotransmitter induced by BDNF in cultured cortical neurons from IUGR(intrauterine growth retardation) rats

  • O2-J-6-2
  • 大島 淑子 / Yoshiko Ooshima:1 沼川 忠広 / Tadahiro Numakawa:1 松本 知也 / Tomoya Matsumoto:2 千葉 秀一 / Shuichi Chiba:3 古田 都 / Miyako Furuta:4 泉 愛子 / Aiko Izumi:1 二宮(馬場) 碧 / Midori Ninomiya-Baba:1 小高 陽樹 / haruki Odaka:1 橋戸 和夫 / Kazuo Hashido:1 安達 直樹 / Naoki Adachi:1 功刀 浩 / Hiroshi Kunugi:1 
  • 1:国立精神神経医療研究センター / Nat'l Inst.of Neurosci., NCNP, Tokyo, Japan 2:広島大学大学院 歯科薬学総合研究科 / Dept DentPhar., Univ of Hiroshima, Hiroshima, Japan 3:武蔵野大学 附置研究所 / Dept Phar., Musashino Univ, Tokyo, Japan 4:聖マリアンナ医科大学 医学部 / Dept Med., St. Marianna Univ, Kanagawa, Japan 

Perinatal complications, including low birth weight, have been proposed to be involved in the onset of psychiatric disorders such as schizophrenia. We have reported that expression levels of TrkB, a high affinity receptor for brain-derived neurotrophic factor (BDNF), was decreased although both ligand BDNF and p75 (low affinity receptor) levels were unchanged in cortical cultures prepared from low birth weight rats (postnatal 1-2 days) by intrauterine growth retardation (IUGR) (Neurosci lett, 2010, 476, 104-9). Here, we examined whether such a reduced TrkB affects phospholipase Cγ(PLCγ) signaling which is one of the TrkB downstream and has a role in the glutamatergic neurotransmission mediated by BDNF. We found that the BDNF-induced glutamate release and activation of PLCγ also were repressed in the IUGR cultures. Both impairments were completely restored after exogenous TrkB transfection. In vivo analysis, we observed that reduced levels of TrkB in the cerebral cortex continued until at least postnatal 7 days, although the weight of IUGR pups recovered. It is possible that reduced TrkB due to IUGR results in downregulation of BDNF-mediated neurotransmission (Neurochem Res., 2014, 39, 785-92). The study was supported by grants from the Grant-in-Aid for Challenging Exploratory Research (JSPS KAKENHI Grant Number 25640019) (T. N.) and for Scientific Research (B) (JSPS KAKENHI 24300139) (T. N.) in the Ministry of Education, Culture, Sports, Science, and Technology of Japan.

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