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Epilepsy, Headache, Vertigo

開催日 2014/9/11
時間 16:00 - 17:00
会場 Poster / Exhibition(Event Hall B)

Diffuse brain dysfunction in Japanese benign adult familial myoclonus epilepsy

  • P1-356
  • 人見 健文 / Takefumi Hitomi:1 小林  勝哉 / Katsuya Kobayashi:2 近藤 孝之 / Takayuki Kondo:2 松本 理器 / Riki Matsumoto:3 寺田 清人 / Kiyohito Terada:4 神田 益太郎 / Masutaro Kanda:5 高橋 良輔 / Ryosuke Takahashi:2 池田  昭夫 / Akio Ikeda:3 
  • 1:京都大院・医・臨床病態検査 / Dept Clin Labo Med, Kyoto Univ Grad Sch of med, Kyoto, Japan 2:京都大院・医・臨床神経 / Dept Neurol, Kyoto Univ Grad Sch of med, Kyoto, Japan 3:京都大院・医・てんかん運動異常生理 / Dept Epilepsy, Movement Disorders and Physiol, Kyoto Univ Grad Sch of med, Kyoto, Japan 4:静岡神経医療センター・てんかん部門 / Dept Epilepsy, National Epilepsy Center, Shizuoka Insti of Epilepsy and Neurological Disorders, Shizuoka, Japan 5:医仁会武田病院・神経内科 / Dept of Neurol, Takeda General Hospital, Kyoto, Japan 

Objectives: To clarify the clinical implication of the maximum frequency of posterior dominant rhythm (PDR) in electroencephalogram (EEG) in benign adult familial myoclonus epilepsy (BAFME).
Methods: Maximum frequency of PDR in EEG was studied in 19 BAFME patients (5 men and 14 women, mean age of 50.6 ± 15.7 years, 26 - 76 years). Regarding control data as EEG normal group, consecutive 102 adults (age of 20 or above) diagnosed as normal in the EEG report (44 men and 58 women, mean age of 38.2 ± 13.9 years, 21 - 77 years) and 38 age-matched subjects (10 men and 28 women, mean age of 50.1 ± 14.5 years, 26 - 77 years) elaborated from them were also studied. We also investigated the chronological change of the frequency of PDR in 9 BAFME patients whom EEG was recorded more than twice.
Results: Maximum frequency of PDR in BAFME was 9.1 ± 0.7 Hz, and it was significantly lower in comparison to that of 102 control subjects (10.5 ± 0.9 Hz) and 38 age-matched control subjects (10.4 ± 1.1 Hz), respectively (P < 0.0001). The finding was also consistent regardless of the anticonvulsant in control subjects. There was a tendency, but not significant, in slowing PDR with age in both BAFME and control subjects. There was no significant chronological change in PDR frequency of 9 BAFME patients.
Conclusions: These findings of PDR frequency in EEG suggest that diffuse brain dysfunction exists in Japanese BAFME. However, PDR slowing with aging in BAFME was quite comparable with that of control subjects, which suggest that diffuse brain dysfunction does not have clear progressive pathophysiology in BAFME.

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