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開催日 2014/9/12
時間 11:00 - 12:00
会場 Poster / Exhibition(Event Hall B)

Parahippocampal dysconnectivity in the At Risk Mental State

  • P2-327
  • 宮田 淳 / Jun Miyata:1,2 ウィントン・ブラウン トビー / Toby Winton-Brown:2 クロスリー ニコラス / Nicolas Karmel Crossley:2 カプール シティシュ / Shitij Kapur:2 マグワイア フィリップ / Philip McGuire:2 
  • 1:京都大学 / Department of Neuropsychiatry, Kyoto University Hospital 2:Institute of Psychiatry, King’s College London, London, UK / Institute of Psychiatry, King’s College London, London, UK 

Dopamine dysfunction may lead to psychotic symptoms through an effect on salience processing (Kapur, 2003). It has been suggested that this dopamine dysfunction is driven by hippocampal overactivity, which influences midbrain dopamine neurons via inputs through the basal ganglia (Lisman and Grace, 2005). On the other hand, independent research suggests that there is a "salience network (SN)" comprising the insula and anterior cingulate cortex (ACC). We used neuroimaging to investigate functional connectivity within and across these two different "salience" networks in people with an At Risk Mental State (ARMS) for psychosis.

Resting state functional MRI (rsfMRI) data were acquired from 29 ARMS subjects and 25 healthy controls (HC). The rsfMRI data were analyzed by independent component analysis. Three networks of interest were identified: hippocampal network (HN), basal ganglia network (BGN), and SN. Group differences in intra-network connectivity analysis within each network were tested, controlling for clusterwise family wise error across all 6 tests. Group differences in inter-network connectivity were calculated by partial correlation between the time series of each network.

ARMS participants had significantly decreased connectivity within the HN and BGN. ARMS participants showed a significantly increased partial correlation between the HN and SN (p<0.05, FWE corrected).

The ARMS was associated with intra-network abnormalities in both the HN and BGN, but not within the SN, and with heightened coupling between the HN and SN. These data provide further support for the role of altered medial temporal connectivity in psychosis, but also implicate the insular-ACC salience network.

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