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Chromatin (Epigenetic) regulation of neuronal development

開催日 2014/9/12
時間 9:00 - 11:00
会場 Room A(Main Hall)
Chairperson(s) 後藤 由季子 / Yukiko Gotoh (東京大学大学院薬学系研究科 / Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan)
内匠 透 / Toru Takumi (理化学研究所 脳科学総合研究センター / RIKEN Brain Science Institute, Japan)

Decoding epigenetics related to distinct phases of long-term memory in Drosophila

  • S2-A-1-1
  • 平野 恭敬 / Yukinori Hirano:1 中村 直介 / Nakamura Naosuke:1 齋藤 実 / Minoru Saitoe:2 
  • 1:京都大学大学院 / Kyoto University Graduate School of Medicine, Japan 2:東京都医学総合研究所 / Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan 

Memory is consolidated to a stable form of memory, long-term memory (LTM), which process requires de novo gene expression mediated by epigenetic regulation. Animals can retrieve LTM if consolidated LTM is properly maintained, although LTM might be extinguished due to the environmental change. These distinct phases and LTM, consolidation, maintenance and extinction, may be regulated by different set of epigenetic regulators and their target genes. If this were the case, decoding epigenetics will provide novel insights into the mechanism of LTM consolidation, maintenance and extinction. Using Drosophila, we first screened the epigenetic modifiers involved in consolidation and maintenance of LTM. As expected, LTM consolidation and maintenance was mediated by different sets of epigenetic modifiers. We then decoded epigenetics related to the identified epigenetic modifiers, and obtained their target genes. Abundant genetic resources in fly allowed us to examine whether the target genes are involved in individual phases of LTM. We found that the identified genes are required for either LTM consolidation, maintenance or extinction, supporting the view that those different phases of LTM are distinct epigenetic regulators and their target genes. This work provides central players of epigenetics regulating distinct phases of LTM, and also suggest a novel concept in which terminally differentiated neurons are still epigenetically processed to adjust the animals' behavior to the changeable environment.

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