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Social Behavior

開催日 2014/9/12
時間 14:00 - 15:00
会場 Poster / Exhibition(Event Hall B)

A Neural Mechanism Underlying Mating Preferences for Familiar Individuals in Medaka Fish

  • P2-272
  • 奥山 輝大 / Teruhiro Okuyama:1,2,3 横井 佐織 / Saori Yokoi:2 大賀 真伊 / Mai Ohka:2 阿部 秀樹 / Hideki Abe:6 磯江 泰子 / Yasuko Isoe:2 末廣 勇司 / Yuji Suehiro:2 今田 はるか / Haruka Imada:2 田中 実 / Minoru Tanaka:3 川崎 隆史 / Takashi Kawasaki:4 弓場 俊輔 / Shunsuke Yuba:4 谷口 善仁 / Yoshihito Taniguchi:5 亀井 保博 / Yasuhiro Kamei:3 大久保 範聡 / Kataaki Okubo:7 島田 敦子 / Atsuko Shimada:2 成瀬 清 / Kiyoshi Naruse:3 武田 洋幸 / Hiroyuki Takeda:2 岡 良隆 / Yoshitak Oka:2 久保 健雄 / Takeo Kubo:2 竹内 秀明 / Hideak Takeuchi:2 
  • 1:マサチューセッツ工科大学 / Massachusetts Institute of Technology 2:東大・院理・生物科学 / Dept. of Biol. Scis., Grad. Sch. of Sci., The Univ. of Tokyo 3:基礎生物学研究所 / Natl. Inst. Basic Biol. 4:産総研 / AIST 5:杏林大・医 / School of Med., Kyorin Univ. 6:名古屋大・院生命農 / Grad. Sch. of Bioagri. Sci., Nagoya Univ. 7:東大・院農 / Grad. Sch. of Agric. and Life Sci., The Univ. of Tokyo 

Social familiarity, which is based on the ability to recognize familiar conspecific individuals following social association, influences mating receptivity in various vertebrates from fish to primates. We previously demonstrated that medaka (Oryzias Latipes) females recognize familiar males following prior visual exposure. Medaka females have high receptivity only to the familiar male. Here, we demonstrate that female receptivity is biphasically regulated by gonadotropin-releasing hormone 3-producing (GnRH3) neurons. GnRH3 neurons, comprising a central neuromodulatory system, receive multimodal sensory information and project their axons throughout the entire brain. To address the function of GnRH3 peptides, which are synthesized specifically in GnRH3 neurons, we searched gnrh3 mutant by targeting induced local lesions in genomes (TILLING) method and identified the gnrh3S27P allele in which a conserved serine residue was changed to proline. Interestingly, the gnrh3S27P/S27P females exhibited low female mating receptivity, irrespective of the visual exposure prior to mating. Our findings strongly suggest that the GnRH3 peptide is required for switching from low to high female receptivity. Furthermore, electrophysiologic analysis revealed that TN-GnRH3 neurons with a basal level of neural activity suppress female receptivity to any male (default mode). Visual exposure prior to mating facilitates TN-GnRH3 neuron activity (facilitated mode), which correlates with high female receptivity to the familiarized male. gnrh3S27P/S27P females have a basal level of neural activity irrespective of the visual exposure, suggesting that GnRH3 peptides are required for the mode-switching of GnRH3 neurons via self-priming.

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