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Stem Cells, Neuronal and Glial Production/Differentiation

開催日 2014/9/11
時間 11:00 - 12:00
会場 Poster / Exhibition(Event Hall B)

The property of dentate granule cell progenitors is altered immediately after birth

  • P1-077
  • 石 龍徳 / Tatsunori Seki:1 皆川 史織 / Shiori Minakawa:1,2 佐藤 亨 / Toru Sato:1 戸田 景子 / Keiko Toda:1 岩室 祥一 / Shoichi Iwamuro:2 塩田 清二 / Seiji Shioda:3 
  • 1:東京医大・組織神経解剖 / Dep Histol Neuroanat, Tokyo Med Univ, Tokyo, Japan 2:東邦大学・理・生物 / Dept Biol, Toho Univ, Chiba, Japan 3:昭和大学・医・解剖 / Dept Anat, Showa Univ, Sch Med, Tokyo, Japan 

During embryonic period, both neocortical and hippocampal neurons are developed from the pallium; neocortical neurons from the lateral and dorsal pallium, and hippocampal neurons from the medial pallium. After birth, neurogenesis ceases in the neocortex, while neurogenesis persists into adulthood in the dentate granule cell layer of the hippocampus. One of important questions is what the difference between neocortical and dentate progenitor cells that allows progenitor cells to continue neurogenesis throughout life is. In the first step to solve the problem, we recently have compared some molecules expressed by these progenitors during embryonic period, and have found that dentate progenitor cells are GFAP+/BLBP-, whereas neocortical ones are GFAP-/BLBP+. Since adult dentate progenitor cells are known to express both GFAP and BLBP, this suggests that GFAP+/BLBP- embryonic progenitor cells are altered into GFAP+/BLBP+ adult progenitor cells that contribute to persistent neurogenesis. Here we examined when the alteration occurs after birth by use of Gfap-GFP mice. From late embryonic to early postnatal periods, proliferative dentate progenitors were located in the ventricular zone, dentate stream (suprafimbrial and subpial regions) and developing dentate region (hilus and granule cell layer). By postnatal day 0 (P0), the progenitors were mostly Gfap-GFP+/BLBP-. At P1 a BLBP expression appeared in 30% of Gfap-GFP+ cells that were distributed in the granule cell layer and hilus. By P14 a half of Gfap-GFP+ cells became to express BLBP. They were mostly seen in the subgranular zone, and had a radial process, a morphological trait of adult type progenitors. These results indicate that the property of the dentate progenitors cells is converted immediately after birth, and become adult type progenitors.

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