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開催日 2014/9/13
時間 11:00 - 12:00
会場 Poster / Exhibition(Event Hall B)

Cross-modal interactions between auditory and somatosensory inputs in the thalamic reticular nucleus: a neural basis for cross-modal modulation of attention and perception

  • P3-179
  • 木村 晃久 / Akihisa Kimura:1 井辺 弘樹 / Hiroki Imbe:1 
  • 1:和歌山県立医科大学 / Dept Physiol, Wakayama Medical Univ, Wakayama, Japan 

The thalamic reticular nucleus (TRN) occupies a highly strategic position to regulate sensory processing in the thalamocortical loop. Given that cross-modal sensory interaction takes place in the TRN, the TRN could play a pivotal role in cross-modal modulation of attention and perception. In fact, diverse sub-threshold interactions between visual and auditory inputs take place in the TRN (Kimura, 2014). To determine whether this cross-modal sensitivity of the TRN could extend across sensory modalities, the present study examined interactions between auditory and somatosensory inputs in single TRN cells using juxta-cellular recording and labeling techniques. Experiments were performed on anesthetized rats. Auditory (noise burst) or somatosensory (electrical stimulation of the hind-paw) stimulation alone and combined stimulation were randomly given. Recordings were obtained from 132 cells that included 86 auditory cells responsive only to sound, 15 somatosensory cells responsive only to electrical stimulation, 22 bi-modal cells and 9 cells responsive only to combined stimulation. Auditory or somatosensory response (unit discharges) was modulated by electrical stimulation or sound, which did not elicit unit discharges, i.e., sub-threshold somatosensory or auditory input, in the majority of recordings (80 auditory and 13 somatosensory cells). Modulated cells sent axonal projections to first- or higher-order thalamic nuclei. Suppression predominated in modulation that took place not only in primary responses but also in late responses repeatedly evoked after sensory stimulation. Combined stimulation also evoked de-novo responses, and modulated response latency and burst spiking. The results suggest that the TRN incorporates sensory inputs of different modalities into single cell activity across sensory modalities. The TRN is thought to exert potentially very extensive cross-modal control of sensory processing that contributes to cross-modal modulation of attention and perception.

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