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演題詳細

Poster

薬物依存、乱用
Drug Addiction and Abuse

開催日 2014/9/12
時間 14:00 - 15:00
会場 Poster / Exhibition(Event Hall B)

外因性アグマチンによるマウスにおける覚せい剤誘発常同行動および過運動の抑制
Exogenous agmatine inhibits methamphetamine-induced stereotypy and hyperlocomotion in mice

  • P2-352
  • 北中 純一 / Junichi Kitanaka:1 北中 順惠 / Nobue Kitanaka:1 Hall F. Scott / F. Scott Hall:2 Uhl George R. / George R. Uhl:2 田中 康一 / Koh-ichi Tanaka:3 西山 信好 / Nobuyoshi Nishiyama:3 竹村 基彦 / Motohiko Takemura:1 
  • 1:兵庫医大・医・薬理 / Hyogo Col. Med. 2:Mol. Neurobiol., NIDA-IRP, Baltimore, MD, USA / Mol. Neurobiol., NIDA-IRP, Baltimore, MD, USA 3:兵庫医療大・薬・薬理 / Div Pharmacol, Dept Pharm, Sch Pharm, Hyogo Univ Hlth Sci, Hyogo, Japan 

We investigated whether pretreatment with agmatine affected methamphetamine (METH)-induced stereotypy and hyperlocomotion in male ICR mice. Agmatine pretreatment alone had no effects on locomotion or stereotypy. Pretreatment of mice with agmatine produced a dose-dependent attenuation of locomotion induced by low dose of METH. Similarly, agmatine pretreatment produced a dose-dependent attenuation of the total incidence of stereotypical behavior induced by a low dose of METH (5 mg/kg). The stereotypy induced by this dose was predominantly characterized by stereotypical sniffing. By contrast, agmatine did not affect the total incidence of stereotypy induced by a higher dose of METH (10 mg/kg). However, the nature of the stereotypy induced by this dose of METH was substantially altered: stereotypical biting was significantly reduced by agmatine pretreatment, while stereotypical sniffing and persistent locomotion were significantly increased by pretreatment with agmatine. Agmatine pretreatment appears to produce a rightward shift in the dose-response curve for METH. This data suggest that the antagonism of METH effects by agmatine should be investigated as a potential treatment for METH addiction or METH overdose.

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