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Drug Addiction and Abuse

開催日 2014/9/12
時間 14:00 - 15:00
会場 Poster / Exhibition(Event Hall B)

Exogenous agmatine inhibits methamphetamine-induced stereotypy and hyperlocomotion in mice

  • P2-352
  • 北中 純一 / Junichi Kitanaka:1 北中 順惠 / Nobue Kitanaka:1 Hall F. Scott / F. Scott Hall:2 Uhl George R. / George R. Uhl:2 田中 康一 / Koh-ichi Tanaka:3 西山 信好 / Nobuyoshi Nishiyama:3 竹村 基彦 / Motohiko Takemura:1 
  • 1:兵庫医大・医・薬理 / Hyogo Col. Med. 2:Mol. Neurobiol., NIDA-IRP, Baltimore, MD, USA / Mol. Neurobiol., NIDA-IRP, Baltimore, MD, USA 3:兵庫医療大・薬・薬理 / Div Pharmacol, Dept Pharm, Sch Pharm, Hyogo Univ Hlth Sci, Hyogo, Japan 

We investigated whether pretreatment with agmatine affected methamphetamine (METH)-induced stereotypy and hyperlocomotion in male ICR mice. Agmatine pretreatment alone had no effects on locomotion or stereotypy. Pretreatment of mice with agmatine produced a dose-dependent attenuation of locomotion induced by low dose of METH. Similarly, agmatine pretreatment produced a dose-dependent attenuation of the total incidence of stereotypical behavior induced by a low dose of METH (5 mg/kg). The stereotypy induced by this dose was predominantly characterized by stereotypical sniffing. By contrast, agmatine did not affect the total incidence of stereotypy induced by a higher dose of METH (10 mg/kg). However, the nature of the stereotypy induced by this dose of METH was substantially altered: stereotypical biting was significantly reduced by agmatine pretreatment, while stereotypical sniffing and persistent locomotion were significantly increased by pretreatment with agmatine. Agmatine pretreatment appears to produce a rightward shift in the dose-response curve for METH. This data suggest that the antagonism of METH effects by agmatine should be investigated as a potential treatment for METH addiction or METH overdose.

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