• Top page
  • Timetable
  • Per session
  • Per presentation
  • How to
  • Meeting Planner

演題詳細

Poster

学習・長期記憶
Learning and Long-term Memory

開催日 2014/9/13
時間 11:00 - 12:00
会場 Poster / Exhibition(Event Hall B)

マウス海馬CA1における錐体細胞および介在細胞サブタイプへの異なったシナプス入力様式
Distinct patterns of synaptic inputs onto pyramidal cell and interneuron subtypes in mouse hippocampal CA1

  • P3-225
  • 森 琢磨 / Takuma Mori:1 吉村 由美子 / Yumiko Yoshimura:1 
  • 1:生理学研究所 / National Institute for Physiological Sciences 

The neurochemical, morphological and physiological properties of interneuron subtypes have been studied extensively. However, the neural circuits consisting of distinct interneuron subtypes have not been well characterized. In this study, we focused on parvalbumin positive interneurons (PV-IN) and calretinin-positive interneurons (CR-IN) in mouse hippocampal CA1, and visualized presynaptic neurons targeting these interneurons using rabies virus monosynaptic tracer and cell-type specific gene expression methods. In addition, we analyzed presynaptic neurons targeting CA1 pyramidal cells (PCs). We confirmed that CA1 PCs received many synaptic inputs from ipsilateral CA3 PCs, and few inputs from excitatory neurons in contralateral CA3, ipsilateral CA1 and ipsilateral medial entorhinal cortex. On the other hand, PV-IN received abundant inputs from ipsilateral CA1 and CA3 cells. CR-IN were mainly innervated by local interneurons in ipsilateral CA1. All these neurons also received inputs from cholinergic neurons in the medial septum. Surprisingly, we found that not only CA1 interneurons, but also CA1 PCs were innervated by parvalbumin positive septal neurons, which were considered to mainly extensively connect to CA1 interneurons previously. These results indicate that each interneuron subtype receives synaptic inputs from distinct sources of cells. It is also indicated that this method tracing connections from specific cell types is very useful to find novel synaptic connections particularly in long-distance connections and sparse connections.

Copyright © Neuroscience2014. All Right Reserved.