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開催日 2014/9/11
時間 11:00 - 12:00
会場 Poster / Exhibition(Event Hall B)

Complex spike response characteristics of Purkinje cells in the cerebellar uvula during optokinetic stimulation

  • P1-135
  • 北間 敏弘 / Toshihiro Kitama:1 駒形 純也 / Junya Komagata:2 
  • 1:山梨大学・総合分析実験センター / Center for Life Science Research, Univ of Yamanashi, Yamanashi, Japan 2:健康科学大学・理学療法学科 / Dept of Physical Therapy, Health Science University, Yamanashi, Japan 

We have been studying the firing characteristics of Purkinje cells (P-cells) in the cerebellar nodulus and uvula of awake cats during sinusoidal head rotation in the vertical plane. The present study examined complex spike (CS) firing during optokinetic stimulation of the P-cells in the uvula. For visual-pattern rotation, a random dot pattern was presented on a monitor that was placed in front of the animal. The random-dot pattern was rotated sinusoidally in the horizontal, vertical, or torsional plane under the control of a computer. The stimulus parameters routinely used for each plane were a frequency of 0.25 Hz and a velocity of 6.28 °/s. In about forty percent of tested cells, a clear firing response was observed for CS activity during visual-pattern rotation in either the vertical or torsional plane, but not in the horizontal plane. The on-direction (stimulus direction that increases the firing rate) of CS firing was upward for cells responding to vertical-rotation and in an extorsional direction for cells responding to torsion-rotation. Velocity specificity was examined using stimulus velocities of 1.6-25.1°/s at a frequency of 0.25 Hz. CS modulation tended to increase with increasing stimulus velocities up to approximately 6.3-12.6°/s, but decreased with larger velocities. Frequency responses were examined using stimulus frequencies of 0.0625, 0.125, 0.25, 0.5, and 1.0 Hz, with a velocity of 6.3-12.6°/s, to evoke the maximal response in each P-cell. The response phases of CS modulation were approximately in phase with the stimulus velocities and the velocity gain had a similar range across the examined frequencies. These results suggest that each CS responds to a stimulus velocity with a specific direction.

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