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Oculomotor System

開催日 2014/9/11
時間 17:00 - 18:00
会場 Room H(304)
Chairperson(s) 杉内 友理子 / Yuriko Sugiuchi (東京医科歯科大学医歯学総合研究科システム神経生理学 / Department of Systems Neurophysiology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan)
伊澤 佳子 / Yoshiko Izawa (東京医科歯科大学大学院医歯学総合研究科 システム神経生理学 / Department of Systems Neurophysiology, Tokyo Medical and Dental University, Japan)

Fixational-saccade related activity of pedunculopontine tegmental nucleus neurons in monkeys

  • O1-H-5-4
  • 小林 康 / Yasushi Kobayashi:1,2,3 岡田 研一 / Ken-ichi Okada:1,2 
  • 1:大阪大学大学院 / Lab of Neuroscience, Grad Sch of Frontier Biosci., Osaka Univ, Suita, Japan 2:脳情報通信融合研究センター / Center for Information and Neural Networks, National Institute of Information and Communications Technology, Suita, Japan 3:大阪大学社会経済研究所 / Osaka University Research Center for Behavioral Economics, Suita, Japan 

Fixational saccades are small, involuntary eye movements that occur during attempted visual fixation and are affected by several cognitive and targeting-saccade related processes. Thus, there might be an interaction between fixational saccade and targeting saccade related signals The pedunculopontine tegmental nucleus (PPTN) has anatomical connections with numerous saccade-related and limbic areas. Previously, we reported that a group of PPTN neurons showed transient phasic bursts or a pause in activity during large visually guided and spontaneous saccades. We hypothesized that single PPTN neurons would relay both fixational saccade- and targeting saccade-related signals, and might function as an interface between motor and cognitive systems. We recorded the activity of PPTN neurons in behaving monkeys during a reward-biased visually guided saccade task, and analyzed neuronal activity for small fixational saccades during visual fixation and compared it with the activity for large targeting saccades and spontaneous saccades during inter-trial interval. A population of PPTN neurons exhibited a fixational saccade-related phasic increase in activity, and the majority of them also showed activity modulation with large targeting saccades. Thus, fixational micro-saccade related signals of PPTN neurons share information with large targeting saccade signals, and might contribute to the cognitive modulation of fixational saccades.

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