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アルツハイマー病、他の認知症、老化 2
Alzheimer's Disease, Other Dementia, Aging 2

開催日 2014/9/11
時間 15:00 - 16:00
会場 Room I(311+312)
Chairperson(s) 山田 麻紀 / Maki K. Yamada (東京大学 大学院医学系研究科 代謝生理化学分野 / Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, The University of Tokyo, Japan)
西村 正樹 / Masaki Nishimura (滋賀医科大学分子神経科学研究センター / Moleculer Neuroscience Research Center, Shiga University of Medical Science, Japan)

Diosgenin-induced cognitive enhancement in normal mice is mediated by 1,25D3-MARRS

  • O1-I-4-1
  • 東田 千尋 / Chihiro Tohda:1 李 英娥 / Young-A Lee:2 後藤 幸織 / Yukiori Goto:2 ネメレ イルカ / Ilka Nemere:3 
  • 1:富山大学・和漢医薬学総合研究所 / Div Neuromedical Science, Inst Natural Med, Univ of Toyama, Japan 2:京都大学・霊長類研究所・認知学習 / Cognition and Learning Sec, Primate Research Inst, Kyoto Univ, Japan 3:Dept Nutrition, Dietetics, and Food Sciences, Utah State Univ, Logan, US / Dept Nutrition, Dietetics, and Food Sciences, Utah State Univ, Logan, US 

We previously reported that diosgenin, a plant-derived steroidal sapogenin, improved memory and reduced axonal degeneration in an Alzheimer's disease mouse model. Diosgenin directly activated the membrane-associated rapid response steroid-binding receptor (1,25D3-MARRS) in neurons. However, 1,25D3-MARRS-mediated diosgenin signaling was only shown in vitro in the previous study. Here, we aimed to obtain in vivo evidence showing that diosgenin signaling is mediated by 1,25D3-MARRS in the mouse brain. Diosgenin treatment in normal mice enhanced object recognition memory and spike firing and cross-correlation in the medial prefrontal cortex and hippocampal CA1. In diosgenin-treated mice, axonal density and c-Fos expression was increased in the medial prefrontal and perirhinal cortices, suggesting that neuronal network activation may be enhanced. The diosgenin-induced memory enhancement and axonal growth were completely inhibited by co-treatment with a neutralizing antibody for 1,25D3-MARRS. Our in vivo data indicate that diosgenin is a memory-enhancing drug and that enhancement by diosgenin is mediated by 1,25D3-MARRS-triggered axonal growth.

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