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RIKEN symposium:Manipulating the sense of reality - The potential of virtual reality for neuroscience in rodents

開催日 2014/9/13
時間 15:00 - 17:00
会場 Room G(303)
Chairperson(s) 片山 統裕 / Norihiro Katayama (東北大学大学院情報科学研究科 / Biomodeling Laboratory, Graduate School of Information Sciences, Tohoku University, Japan)
佐藤 正晃 / Masaaki Sato (科学技術振興機構さきがけ / Japan Science and Technology Agency / RIKEN BSI, Japan)

A novel virtual reality system used to understand neural mechanisms that underlie active touch in mice

  • S3-G-1-2
  • 村山 正宜 / Masanori Murayama:1 
  • 1:独立行政法人 理化学研究所 行動神経生理学研究チーム / RIKEN BSI Lab. for Behavioral Neurophysiology, Japan 

Active touch is thought to require the integration of somatosensory and motor systems. However, little is known about the neural mechanisms underlying perception of active touch. In previous studies, we showed that the hindlimb region of the primary somatosensory cortex (S1HL) and the higher-order motor cortex form a reverberant circuit that is activated during hindlimb stimulation. We also showed that optogenetic inactivation of inputs from the motor area to S1HL causes inaccurate somatic perception in behaving mice. These results suggest that motor input to the sensory area is necessary for perception and that somatomotor integration occurs in the sensory area. In order to test this, we developed a multidisciplinary approach that would allow us to record and manipulate neural activity in behaving animals. We designed a virtual reality system where tactile stimulation could be delivered to mice while they were running through a simulated environment. The heads of the mice were fixed so that we could record and manipulate neural activity during the simulation. We present this system in detail along with the physiological recordings obtained from the S1HL during tactile stimulation.

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