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Animal Experimental Models

開催日 2014/9/13
時間 18:10 - 19:10
会場 Room H(304)
Chairperson(s) 渡我部 昭哉 / Akiya Watakabe (基礎生物学研究所 脳生物学研究部門 / Division of Brain Biology, National Institute for Basic Biology, Japan)
西川 徹 / Toru Nishikawa (東京医科歯科大学 大学院 精神行動医科学分野 / Section of Psychiatry and Behavioral sciences, Graduate School of Medical and Dental Sciences,Tokyo Medical and Dental University, Japan)

Altered Social Behavior by Monosodium Glutamate is mediated by Vagus Nerve Afferent in ADHD Model Rat

  • O3-H-6-2
  • 飛田 秀樹 / Hideki Hida:1 横山 善弘 / Yoshihiro Yokoyama:1 清水 由布子 / Yuko Shimizu:1 三角 吉代Sachiyo Misumi 石田 章真 / Akimasa Ishida:2 鄭 且均 / Cha-Gyun Jung:1 
  • 1:名古屋市立大学 / Nagoya City Univ Grad Sch Med Sci, Japan 

Attention-deficit hyperactivity disorder (ADHD) is characterized by hyperactivity, impulsivity and inattention. Dysfunction of mesocorticolimbic dopaminergic system such in the amygdala (Amy) and prefrontal cortex (PFC) is related to emotional regulation in ADHD. Spontaneously hypertensive rat (SHR) is known as an ADHD model. We previously revealed that oral intake of monosodium L- glutamate (MSG), a taste substance for umami, for 5 weeks from postnatal day 25 (P25) to P60 altered social behavior in SHR that was grown in single isolated condition: parameters for sociality (sniffing time and riding) were significantly reduced in the MSG group in social interaction test. However, the mechanism of the effect of MSG intake during the period of development on enhanced sociality in adulthood is still unknown. We first investigate the changes of dopamine receptor expression (D1R, D2R) in the Amy and PFC using real-time PCR. Expression of D1R and D2R in the Amy was significantly increased in MSG-treated group, while that in the PFC was not changed by MSG intake. We then investigate the effect of brain-gut communication via vagus nerve on the MSG effect. The vagotomy at stomach level was performed in isolated SHR at P25 followed by MSG (0.6% solution) intake for 5 weeks. Social interaction test revealed that the vagotomy in MSG-treated group caused the increase of sniffing time and riding number to the same level as H2O-treated control group. However, no difference was observed in open-field by the vagotomy. Data suggest that MSG effect on social behavior during the period of development was mediated by the afferent of vagus nerve from the gastrointestinal tract receptor, regulating the dopaminergic system in the Amy.

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