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Synaptic Plasticity

開催日 2014/9/11
時間 11:00 - 12:00
会場 Poster / Exhibition(Event Hall B)

Multiple splice variants of Rab effector protein, rabaptin-5, are critical molecules for glutamate receptor trafficking at synapses

  • P1-053
  • 清末 和之 / Kazuyuki Kiyosue:1 亀山 仁彦 / Kimihiko Kameyama:2 
  • 1:産業技術総合研究所 / Human Health Research institute, National Institute of Advanced Industrial Science and Technology 2:東大・医・超高齢社会感覚認知運動機能医学 / Department of Sensory-recognition and Locomotive-function Sciences in the Super-aged Society, The University of Tokyo 

The control of glutamate receptor delivery to the synapse is a mechanism that is critical for defining synaptic strength and potential of plasticity. To date, it remains unclear whether synaptic activation history controls receptor trafficking at the synapse. Rabaptin-5 is known to be participated in end some function with rab5. We previously reported that over expression of rabaptin-5 promotes GluA1 surface delivery and rabaptin-5 is down-regulated by substantial synaptic activity. These data indicate that rabaptin-5 is a key mediator for metaplasticity.
Rabaptin-5 is ubiquitously expressed and has multiple spliced variants. To further characterize the role of rabaptin-5, we examined these expression in central nervous system. We confirm at least two transcripts, rabaptin-5 and rabaptin-4. Although rabaptin-4 is a splice variant lacking rab5 binding domain, this spliced variant did not show activity dependent decrease, which are observed in the case of rabaptin-5. This would support activity independent AMPA receptor trafficking via rabaptin-4. These results indicate that these spliced variants can mediate receptor traffickings via activity dependent and/or independent manner.
A part of this work was supported by KAKENHI (20500304)

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