• Top page
  • Timetable
  • Per session
  • Per presentation
  • How to
  • Meeting Planner



Sleep and Biological Rhythms

開催日 2014/9/12
時間 9:00 - 10:00
会場 Room H(304)
Chairperson(s) 八木田 和弘 / Kazuhiro Yagita (京都府立医科大学大学院医学研究科統合生理学 / Department of Physiology and Systems Bioscience, Kyoto Prefectural University of Medicine, Japan)
人見 健文 / Takefumi Hitomi (京都大学大学院 医学研究科 臨床病態検査学講座 / Department of Clinical Laboratory Medicine, Kyoto University, Graduate school of Medecine, Japan)

Dynamic modulation of inter-areal neuronal integrity during sleep: evidence from high frequency activities induced by direct cortical stimulation in human

  • O2-H-1-3
  • 宇佐美 清英 / Kiyohide Usami:1,2 松本 理器 / Riki Matsumoto:1,3 人見 健文 / Takefumi Hitomi:4 小林 勝哉 / Katsuya Kobayashi:1 下竹 昭寛 / Akihiro Shimotake:1 菊池 隆幸 / Takayuki Kikuchi:5 国枝 武治 / Takeharu Kunieda:5 三國 信啓 / Nobuhiro Mikuni:5,6 宮本 享 / Susumu Miyamoto:5 福山 秀直 / Hidenao Fukuyama:7 高橋 良輔 / Ryosuke Takahashi:1 池田 昭夫 / Akio Ikeda:1,3 
  • 1: 京都大院・医・臨床神経学 / Dept Neurol, Kyoto Univ, Kyoto, Japan 2:洛和会音羽病院 神経内科 / Dept Neurol, Rakuwakai Otowa HP, Kyoto, Japan 3:京都大院・医・てんかん・運動異常生理学 / Dept Epilepsy, Movement Disorders and Physiology, Kyoto Univ, Kyoto, Japan 4:京都大院・医・呼吸管理睡眠制御学 / Dept Resp Care Sleep Ctrl Med, Kyoto Univ, Kyoto, Japan 5:京都大院・医・脳神経外科学 / Dept Neurosurg, Kyoto Univ, Kyoto, Japan 6:札幌医大院・医・脳神経外科学 / Dept Neurosurg, Sapporo Med Univ, Sapporo, Japan 7:京都大院・医・脳機能総合研究センター / Human Brain Res Center, Kyoto Univ, Kyoto, Japan 

Introduction: Single-pulse electrical cortical stimulation (SPES) has been used to probe cortico-cortical connectivity in human epilepsy patients by recording cortico-cortical evoked potentials (CCEPs). In this study, we employed CCEP-related high-gamma activities (HGA), namely, SPES-induced HGA (iHGA) as macroscopic proxies for neuronal activities or spiking synchrony, and aimed to investigate dynamic modulation of inter-areal neural processing during sleep.
Methods: We analyzed iHGA in our patient cohort where we investigated modulation of CCEP during sleep (Usami et al., Neuroscience 2012)(IRB#443). The cohort consisted of 12 epilepsy patients who underwent invasive presurgical evaluations with subdural electrodes. We particularly investigated iHGA in association with CCEP components- 1st sharp (N1) and 2nd slow (N2) negative components.
Results: iHGA power increase, namely, increased neuronal synchrony, occurred at N1 phase in all sleep stages and had positive correlation with N1 size. Significant iHGA power decrease immediately followed along the ascending slope of N2 especially in non-REM sleep. The degree of iHGA decrease showed positive correlation with N2 size. While this neuronal inhibition was observed globally during non-REM sleep, only the frontal lobe significantly showed rebound HGA increase or hyper-synchronized overshoot after the intense inhibition.
Conclusions: According to the integrated information theory (Tononi 2008), immediate global inhibition after transient neuronal synchrony in non-REM sleep might explain the physiological basis of unconsciousness during sleep. Significant rebound synchrony in the frontal lobe likely indicates its role in memory consolidation and nocturnal seizures in frontal lobe epilepsy.

Copyright © Neuroscience2014. All Right Reserved.