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Stem Cells, Neuronal and Glial Production/Differentiation

開催日 2014/9/12
時間 11:00 - 12:00
会場 Poster / Exhibition(Event Hall B)

Bcl11b/Ctip2 controls the fate-choice of olfactory sensory neurons

  • P2-083
  • 西田 秀史 / Hidefumi Nishida:1 榎本 孝幸 / Takayuki Enomoto:2 藤田 暁人 / Akito Fujita:1 岩田 哲郎 / Tetsuo Iwata:1 木南 凌 / Ryo Kominami:3 應本 真 / Makoto Ohmoto:4 松本 一朗 / Ichiro Matsumoto:4 廣田 順二 / Junji Hirota:1,2 
  • 1:東京工業大学大学院 生命理工学研究科 生物プロセス専攻 / Dept. of Bioeng., Grad. Sch. of Biosci. and Biotech., Tokyo Inst. of Tech., Yokohama, Japan 2:東京工業大学 バイオ研究基盤支援総合センター / Center for Biological Resources and Informatics, Tokyo Inst. of Tech., Yokohama, Japan 3:新潟大学大学院 医歯学総合研究科 分子細胞医学専攻 / Dept. of Mol. Genet., Grad. Sch. of Med. and Dent. Sci., Niigata Univ., Niigata, Japan 4:モネル化学感覚研究所 / Monell Chemical Senses Center, Philadelphia, U. S. A. 

Olfactory sensory neurons (OSNs) in the main olfactory epithelium (MOE) detect a large number of odorant molecules with odorant receptors (ORs). In mouse, ~1,200 OR genes have been identified. An individual OSN expresses a single OR gene from this large gene repertoire. OR genes can be classified into two phylogenetically distinct groups, class I and class II. Recently, it has been reported that two types of OSNs are fated to choose either class I or class II OR gene repertoires. However, the mechanism underlying the OR-class choice is not understood. Here we show that the transcription factor Bcl11b/Ctip2 controls the fate-choice of two OSN-types. Bcl11b expression in OSNs is dependent on the class of ORs that they express. Loss of Bcl11b function changed the balance between class I and class II OSNs. This was evident both from OR gene expression and from axonal projection of each class of OSNs. Interestingly, OSN-specific Bcl11b-depletion also disturbed the dichotomy of OSNs as in conventional knockout, suggesting that the fate of OSNs is not completely determined even after terminal differentiation. Moreover, gain of function experiment of Bcl11b gave further information on the machinery for OSN fate-choice mediated by Bcl11b. Thus Bcl11b plays an essential role in the balanced production of class I and class II OSNs.

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