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Behavioral Pharmacology

開催日 2014/9/13
時間 11:00 - 12:00
会場 Poster / Exhibition(Event Hall B)

Roles of serotonin and serotonin-1A receptor during the postnatal period in the anxiety, depression, and the spatial learning in adult BALB/c mice

  • P3-351
  • 石川 千尋 / Chihiro Ishikawa:1 大谷 彰子 / Akiko Ohtani:1 吉川 雅朗 / Masaaki Yoshikawa:2 増田 知之 / Tomoyuki Masuda:1 志賀 隆 / Takashi Shiga:1 
  • 1:筑波大院 人間総合科学感性認知脳科学 / Prog in Kansei, Behav and Brain Sci, Grad Sch of Comp Human Sci, Univ of Tsukuba, Ibaraki, Japan 2:日大医機能形態生体構造医 / Dept of Funct Morphol, Nihon Univ Sch of Med, Tokyo, Japan 

Serotonin (5-hydroxytryptamine, 5-HT) is known to act as a neurotrophic factor and modulate synapse formation in the brain development. Also, abnormality in 5-HTergic system leads to psychiatric disorders, such as anxiety disorder and depression, and disability of learning and memory. Previously, we have reported that treatment of fluoxetine, selective 5-HT reuptake inhibitor, during postnatal day (PD) 1-21 decreased anxiety-like behavior significantly in elevated plus maze and decreased depression-like behavior in forced swim test in adult BALB/c mice. It also improved spatial learning in Morris water maze. However, it is unknown that which 5-HT receptor mediates the effects and what are the underlying brain mechanisms of anxiety, depression, and spatial learning. Among 14 5-HT receptor subtypes, 5-HT1A-receptor is expressed widely from the early life. Therefore, we compared the roles of 5-HT1A-receptor in anxiety, depression, and spatial learning in adult BALB/c mice with those of 5-HT. We administered orally either fluoxetine (5 mg/kg BW/day) or 8-OH-DPAT, 5-HT1A-receptor agonist (5 mg/kg BW/day) during PD1-21. We also measured mRNA levels of 5-HT1A-receptor and brain-derived neurotrophic factor (BDNF) in medial prefrontal cortex, amygdala, dorsal and ventral hippocampi, and dorsal raphe, at PD22 and PD71. Fluoxetine increased mRNA expression of 5-HT1A-receptor and BDNF in the ventral hippocampus, which has been shown to be related to anxiety, at PD22. Therefore, it is suggested that BDNF may mediate anxiety-like behavior. On the other hand, while 8-OH-DPAT treatment significantly decreased anxiety-like behavior, it increased depression-like behavior. BDNF mRNA expression was unchanged in any examined brain regions both at PD22 and PD71. Therefore, it is suggested that other factors also play a role in anxiety.

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