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Sensorimotor Learning/Plasticity

開催日 2014/9/13
時間 14:00 - 15:00
会場 Poster / Exhibition(Event Hall B)

Pre and postnatal effects of extremely low frequency electric fields on mismatch negativity component of the auditory event related potentials

  • P3-108
  • Piraye Yargicoglu Akkiraz:1 Deniz Akpinar:2 Deniz Kantar Gok:2 Mutay Aslan:3 Sukru Ozen:4 Aysel Agar:5 
  • 1:Akdeniz University,Faculty of Medicine 2:Akdeniz University,Faculty of Medicine, Department of Biophysics 3:Akdeniz University,Faculty of Medicine, Department of Biochemistry 4:Akdeniz University, Engineering Faculty, Department of Electrical and Electronics Engineering  5:Akdeniz University,Faculty of Medicine, Department of Physiology 

Most public exposure to extremely low frequency electric fields (ELF-EFs) comes from electrical appliances, alternating current (AC) transmission and distribution lines. There was no study examining pre and postnatal effects of 50 Hz EF on the Mismatch Negativity (MMN) component of event-related potentials recorded from rats. Therefore, our study aimed to investigate MMN, apoptosis and oxidative brain damage in rats exposed to pre and postnatal 50 Hz EF at 12 kV/m intensity for 1 hour per day. Forty Wistar male rats were divided into three groups; Control (C), Prenatal group were exposed to EF during pregnancy, postnatal group were exposed to EF after pregnancy for three months (Po). Pregnant rats of Pr group were exposed to 50 Hz EF (12 kV/m; 1 h/day) while those of C and Po groups were not exposed to EF during pregnancy. Following parturition, rats of Po group were exposed to EF whereas rats of C and Pr groups were kept under the same experimental conditions without being exposed to any EF during 90 days. On post natal day 90, MMN were recorded in urethane-anesthetized rats by electrodes positioned stereotaxically to the surface of the dura. After recordings, brain tissues were removed for histological and biochemical analysis. There were differences in the amplitudes of MMN between the responses to the standard and the deviant tones in all groups. 4-hydroxy-2-nonenal (4-HNE) levels were increased in the Po groups in comparison with the C group. In conclusion, electric field decreased MMN amplitudes possiby induced by lipid peroxidation.

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