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Neurodevelpmental Disorders and Schizophrenia

開催日 2014/9/13
時間 9:00 - 10:00
会場 Room I(311+312)
Chairperson(s) 内匠 透 / Toru Takumi (独立行政法人理化学研究所 / RIKEN Brain Science Institute, Japan)
神尾 陽子 / Yoko Kamio (国立精神・神経医療研究センター 精神保健研究所 児童・思春期精神保健研究部 / Department of Child and Adolescent Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry, Japan)

Aberrant resting state functional connectivities with amygdala in autism spectrum disorder

  • O3-I-1-3
  • 丁 ミンヨン / Minyoung Jung:1,2,3 齋藤 大輔 / Daisuke Saito:1,3 石飛 信 / Makoto Ishitobi:4 守田 知代 / Tomoyo Morita:1 猪原 敬介 / Keisuke Inohara:5 佐々木 章宏 / Akihiro Sasaki:6,7 新井 清義 / Sumiyoshi Arai:1,3 升谷 泰裕 / Yasuhiro Masuya:3 藤岡 徹 / Toru Fujioka:3 岡本 悠子 / Yuko Okamoto:1,3 棟居 俊夫 / Toshio Munesue :1,8 友田 明美 / Akemi Tomoda:1,3 定藤 規弘 / Norihiro Sadato:9 岡沢  秀彦 / Hidehiko Okazawa:1,3 飯高 哲也 / Tetsuya Iidaka:10 和田  有司 / Yuji Wada:1,3 小坂 浩隆 / Hirotaka Kosaka:1,3 
  • 1:大阪大連合小児発達学研究科 / United Graduate School of Child Develop, Osaka Univ, Japan 2:日本学術振興会特別研究員 / Research Fellow of JSPS, Japan 3:福井大 / Univ of Fukui, Japan 4:国立精神神経医療センター / NCNP, Japan 5:電気通信大 / Univ of Electro-Communications, Japan 6:大阪市大 / Osaka City Univ, Japan 7:理研 / RIKEN, Japan 8:金沢大 / Kanazawa Univ, Japan 9:生理研 / NIPS, Japan 10:名古屋大 / Nagoya Uni 

Objectives: A number of neuroimaging studies indicate that individuals with autism spectrum disorder (ASD) show dysfunctions and underconnectivities in social brain. Although the amygdala has a central role in social cognition, little is known about the involved networks and corresponding dysfunctions. Therefore, the aim of this study was to investigate the resting state functional connectivities (rs-FCs) with the amygdala in individuals with ASD compared to individuals with typical development (TD).
Methods: Resting-state functional MRI and seed based approach were used to investigate the rs-FCs of amygdala in twenty male individuals with ASD and twenty-five age- and IQ-matched healthy male with TD. In the preprocessing, resting-state data were corrected as proposed in a previous study (Weissenbacher et al., 2009). Individual voxel-wise functional connectivity maps were calculated using the right and left amygdala seed region.
Results: In the ASD group compared with the TD group, substantially smaller areas were functionally connected from the amygdala seed. Significant weaker rs-FCs from the right amygdala seed were observed in the cingulate gyrus, the paracentral lobule and postcentral gyrus in ASD group. However, we found that individuals with ASD demonstrated stronger rs-FCs from the left amygdala seed in the fusiform gyrus, lingual gyrus, and cerebellum.
Conclusion: Our findings suggest that differential strength of rs-FCs with amygdala exists in patients with ASD. This aberrant amygdala functions may explain ''amygdala hyperarousal model'', and may have effects on activity in other brain. We conclude that functional connectivities in the ASD brain during resting-state may reflect dysfunctional social brain including different patterns of functional connectivity in amygdala.

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