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Parkinson's Disease and Related Disorders

開催日 2014/9/12
時間 11:00 - 12:00
会場 Poster / Exhibition(Event Hall B)

Brain neural networks related to Parkinson's disease: A resting state functional MRI study

  • P2-303
  • 髙 真守 / Jinsoo Koh:1 金桶 吉起 / Yoshiki Kaneoke:2 堂西 倫弘 / Tomohiro Donishi:2 森 めぐみ / Megumi Mori:1 中山 宜昭 / Yoshiaki Nakayama:1 阪田 麻友美 / Mayumi Sakata:1 村田 顕也 / Ken-ya Murata:1 寺田 正樹 / Masaki Terada:3 伊東 秀文 / Hidefumi Ito:1 
  • 1:和歌山県立医大医神経内科 / Dept Neurol, Wakayama Medical University, Wakayama, Japan 2:和歌山県立医大医生理一 / Dept System Neurophysiology, Wakayama Medical University, Wakayama, Japan 3:和歌山南放射線科クリニック / Wakayama-minami radiology clinic 

Objective Various motor and nonmotor symptoms in patients with Parkinson's disease (PD) may arise from the abnormal function of neural networks in the brain, and the function of these networks may be altered by anti-Parkinsonian drugs. We conducted functional connectivity (FC) analysis using resting-state functional MRI (rs-fMRI) to investigate neural networks specific to PD and the effect of anti-parkinsonian drugs. Methods We conducted rs-fMRI using 3 tesla MRI to examine consecutive 70 patients with PD (mean age 66.4 ± 8.6 y.o., 31 men and 39 women) and 23 healthy controls (HCs) (mean age 63.5 ± 10.5 y.o., 15 men and 8 women), and calculated the regional global connectivity (rGC) as an index of each region's mean FC between the region and all other regions using cross correlation function. Student's t-test was performed to compare rGC value between patients and HCs, and partial correlation was also performed to examine relationships between rGC and PD symptom scores (MDS-UPDRS), neuropsychological tests (Mini-Mental State Examination, Frontal Assessment Battery, Stroop test), Barratt Impulsiveness Scale 11th version (BIS-11) and drug doses, adjusted for age. Results and Conclusion The rGC values in patients were significantly larger than those for HCs in the wide brain regions such as anterior cingulate, inferior orbital, fusiform, lingual gyri, hippocampus, vermis and cerebellar hemispheres. In the peri-central sulcus, middle temporal gyrus, and posterior lobe, the rGC values for the patients were inversely related to part 3 score of MDS-UPDRS. The values in right lingual gyrus were related to the BIS-11 score. The values in orbitofrontal cortex, accumbens, and insula were related to the levodopa dose, and the values in the posterior lobe, fusiform, middle frontal, caudate, thalamus, and hippocampus were related to the dopamine agonist dose. The results suggest that PD symptoms are caused by the neural network dysfunction outside the basal ganglia, and that anti-parkinsonian drugs affect neural networks involving wide brain regions.

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