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Behavioral Pharmacology

開催日 2014/9/13
時間 14:00 - 15:00
会場 Poster / Exhibition(Event Hall B)

Effects of antidepressants on encounter-induced hyperactivity in isolation-reared mice

  • P3-350
  • 長谷部 茂 / Shigeru Hasebe:1 吾郷 由希夫 / Yukio Ago:1 西山 早紀 / Saki Nishiyama:1 岡 智史 / Satoshi Oka:1 中森 大貴 / Daiki Nakamori:1 田熊 一敞 / Kazuhiro Takuma:1 松田 敏夫 / Toshio Matsuda:1,2 
  • 1:大阪大院・薬・薬物治療 / Lab. of Medicinal Pharmacol., Grad. Sch. of Pharmaceut. Sci, Osaka Univ., Osaka, Japan 2:大阪大院・連合小児発達 / Unit-Grad. Sch. of Child Dev., Osaka Univ., Kanazawa Univ., Hamamatsu Univ. Sch. of Med., Chiba Univ., Fukui Univ., Osaka, Japan 

We recently showed that encounter with an intruder induces hyperactivity in isolation-reared mice and this is associated with a transient activation of prefrontal dopaminergic and serotonergic systems (Neuropsychopharmacology 2013). The novel abnormal behavior hyperactivity was inhibited by drugs which affect serotonin, γ-aminobutyric acid and glutamate systems (Int J Neuropsychopharmacology 2014). To clarify the pharmacological profile of the encounter-induced hyperactivity, we examined the effects of various antidepressants and related drugs on the behavior in isolation-reared mice. An isolation-reared mouse was placed in the large compartment, which was divided by a mesh partition into smaller compartments. An intruder mouse was introduced into the unoccupied small compartment. The behaviors of the resident mouse were videotaped, and analyzed using the ANY-maze video tracking software. Encounter with an intruder increased markedly the locomotion of an isolation-reared mouse and the hyperactivity was repeatedly observed at least for 2 weeks. All antidepressants including the tricyclic antidepressant desipramine, the serotonin reuptake inhibitors fluvoxamine and citalopram and the serotonin/noradrenaline reuptake inhibitors venlafaxine and duloxetine inhibited the hyperactivity in isolation-reared mice without any effect on the locomotion in group-reared mice. In contrast, haloperidol did not inhibit the hyperactivity at the dose which had no effect on the locomotion in group-reared mice. This study shows that encounter-induced hyperactivity in isolation-reared mice is inhibited by various antidepressants. The results suggest that the encounter response of isolation-reared mice is a depressive-like behavior and is a behavioral phenotype sensitive to antidepressants.

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