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Olfaction, Taste, Chemical Senses

開催日 2014/9/13
時間 11:00 - 12:00
会場 Poster / Exhibition(Event Hall B)

Relationship between amygdala and somatosensory cortex for limbs (S1FL/HL) in regulation of sucrose preference by body weight

  • P3-141
  • 朝比奈 洋子 / Yoko Asahina:1 藤原 宏子 / Hiroko Eda-Fujiwara:2 佐藤 亮平 / Ryohei Satoh:3 八十島 安伸 / Yasunobu Yasoshima:4 宮本 武典 / Takenori Miyamoto:1 
  • 1:日本女子大・院理・物質生物機能・生体情報科学 / Lab Behav Neurosci, Div Biol Sci, Grad Sch Sci, Japan Women's Univ, Tokyo, Japan 2:人間総合科学大・人間科学・人間科学 / Dept of Human Arts Sciences, Univ of Human Arts and Sciences, Saitama, Tokyo 3:北里大学・医・生理 / Dept Physiol, Sch Med, Kitasato Univ, Kanagawa, Japan 4:大阪大学・院人間科学・行動生理 / Div Behav Physiol, Dept of Behav Sci, Grad Sch of Human Sci, Osaka Univ, Osaka, Japan 

In our previous studies, food-restricted mice preferred high-caloric sweetener sucrose (Suc), and amygdala lesions inhibited the Suc preference. Mice consumed high-caloric Suc rather than non-caloric sodium saccharin (Sac), when their body weight (BW) of mice reduced to 75% of the original BW for 3 to 6 days by chronic food-restriction. However, Suc consumption abruptly dropped to Sac consumption levels (Saltatory Suppression of Suc Preference; SSSP) immediately after the regain their original BW. The SSSP tended to be suppressed by lesions of somatosensory area for the limbs (S1FL/HL). In the present experiment, we examined the expression of a neuronal activity marker c-Fos in amygdala and S1FL/HL to clarify the relationship between those brain regions. The number of c-Fos positive cells in amygdala of pre-SSSP group was significantly higher than that of post-SSSP group. In contrast, the number of c-Fos positive cells in S1FL/HL of pre-SSSP group was lower than that of post-SSSP group. These results suggest that the sensory activation of S1FL/HL encoding increment of BW decreases amygdala function, resulting in suppression of Suc preference.

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