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Neuroendocrine System

開催日 2014/9/12
時間 11:00 - 12:00
会場 Poster / Exhibition(Event Hall B)

Lysine and ornithine stimulate but arginine suppresses gastrointestinal motility

  • P2-205
  • 中戸 絢也 / Junya Nakato:1 Ho Yin Yee / Yin Yee Ho:1 金子 賢太朗 / Kentaro Kaneko:1 水重 貴文 / Takafumi Mizushige:1,2 金本 龍平 / Ryuhei Kanamoto:1 大日向 耕作 / Kousaku Ohinata:1 
  • 1:京都大学大学院農学研究科食品生物科学専攻 / Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University 2:京都大学学際融合教育研究推進センター生理化学研究ユニット / Res. Unit for Physiol. Chem., C-PIER, Kyoto Univ. 

The gastrointestinal (GI) tract is an organ that senses a variety of nutrients including amino acids. We investigated the effects of basic amino acids, such as L-arginine (Arg), L-lysine (Lys), and L-ornithine (Orn), on GI motility. To evaluate GI motility, we measured small intestinal transit, determined by the distance that a test meal colored with Evans blue travelled in the small intestine.
Orally administered Lys and Orn increased the travelling distance of the test meal, suggesting that Lys and Orn stimulates GI motility. In contrast, Arg decreased it, suggesting that Arg suppresses GI motility. GI motility is known to be stimulated by acetylcholine via nitric oxide (NO) release. To investigate the involvement of the acetylcholine-NO system, atropine and L-NAME, an antagonist of the muscarinic acetylcholine receptor and an inhibitor of NO synthase, respectively, were used. The increase in small intestinal transit induced by Lys and Orn was inhibited by both atropine and L-NAME. These results suggest that the acetylcholine-NO system is involved in the stimulatory effects of Lys and Orn on GI motility.
The Arg-induced inhibitory effect on GI motility was not blocked by lorglumide, an antagonist of cholecystokinin, which is known to suppress GI motility. Furthermore, the Arg-induced inhibitory effect on GI motility was not blocked by atropine, an antagonist that blocks the effects of Lys and Orn. Taken together, the mechanism sensing Lys and Orn may be independent of that of Arg.

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