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Receptors and Transporters

開催日 2014/9/11
時間 16:00 - 17:00
会場 Poster / Exhibition(Event Hall B)

Dry mouth related antidepressant desipramine suppresses salivary AQP5 trafficking

  • P1-034
  • Keimin Lee:1 Kyungpyo Park:1 Se-Young Choi:1 
  • 1:Department of Physiology and Dental Research Institute, Seoul National University, School of Dentistry, Seoul, Korea 

Xerostomia is common disease that reduce amount of saliva in dentistry. There are many reasons of Xerostomia. Among the reasons, taking medicine is typical case in Xerostomia. Many kinds of drug is known as causing of Xerostomia. Antidepressants reduce secretion of saliva, then rampant caries and other oral disease occur. Desipramine is tricyclic anti-depressant that use the treatment of neuropathic pain and major mood disorder. Desipramine increases extracellular catecholamine by strongly inhibiting the re-uptake of catecholamine. Acoordingly, the effect of a stergthened adrenerginc signaling appears which is caused by catecholamine. however, acitivity of catecholamine re uptake in salivary cells cannot by confirmed and catecholamine is known to have no significant connection with water secretion in studies related to the sympathetic nerves distributed in salivary glands. Acetylcholine is the most important neurotarnsmitter that regulates the activity of salivary glands. Cytosolic calcium is induced by responding to acetylcholine which is secreted from parasympathetic nerve endings and the expression of muscarinic M3 receptors in salivary glands. this increase in cytosolic calcium plays a decisive role in incrasing secretions of saliva. Thus, the hypothesis that xerostomia caused by desipramine is due to the regulation of receptor-mediated calcium signaling is possible. however, tricyclic antidepressants which are similar to desipramine are not known to affect receptor-mediated slivary calcium signaling of salivary glands. therefore, by examining the effect of desipramine on receptor-mediated salivary calcium signaling and Aquaporin5 traffciking focusing on muscarinic receptor and histamine receptor with the aim of studying molecular excitation of desipramine Xerogenic effect

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