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突起伸展・回路形成 1
Axonal/Dendritic Growth and Circuit Formation 1

開催日 2014/9/13
時間 15:00 - 16:00
会場 Room J(313+314)
Chairperson(s) 古川 貴久 / Takahisa Furukawa (大阪大学蛋白質研究所 分子発生学研究室 / Laboratory for Molecular and Developmental Biology, Institute for Protein Research, Osaka University, Japan)
大森 義裕 / Yoshihiro Omori (大阪大学蛋白質研究所 / Institute for Protein Research, Osaka University, Japan)

Molecular remodeling of the presynaptic active zone of Drosophila photoreceptors via an activity-dependent feed-back signal

  • O3-J-3-1
  • 鈴木 崇之 / Takashi Suzuki:1 杉江 淳 / Atsushi Sugie:2 羽毛田 聡子 / Satoko Hakeda:1,4 鈴木 えみ子 / Emiko Suzuki:3 Tavosanis Gaia / Gaia Tavosanis:2 
  • 1:東工大・生命理工 / Grad Schl Biosci & Biotech, Tokyo Institute of Technology, Yokohama, Japan 2:DZNE、ボン、ドイツ / DZNE, Bonn, Germany 3:国立遺伝研構造遺伝学研究セ遺伝子回路 / National Inst Genetics, Mishima, Japan 4:日本学術振興会特別研究員 / JSPS Fellow, Japan 

Neural activity contributes to the regulation of the properties of synapses in sensory systems, allowing for adjustment to a changing environment. Little is known about how synaptic molecular components are regulated to achieve activity-dependent synaptic plasticity in central synapses. Here, we found that the presynaptic active zone in Drosophila photoreceptors undergoes structural and molecular remodeling, including Bruchpilot and DLiprin-α, upon mild but prolonged light exposure. The levels of neuronal activity of photoreceptors and of depolarization of their postsynaptic neurons are critical for the light-induced changes in photoreceptor active zone composition, suggesting the existence of a feedback signal. In search of the signal, we found that a reorganization of the microtubule meshwork acts downstream of the divergent canonical Wnt pathway, potentially via the kinesin-3 Immaculate connections. These data reveal changes in composition of active zones at central synapses upon natural stimuli and the molecular machinery that actively contributes to them.

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