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Drug Development

開催日 2014/9/13
時間 11:00 - 12:00
会場 Poster / Exhibition(Event Hall B)

Effect of medial habenular activity on nicotine aversion in repeated nicotine-exposed rats

  • P3-051
  • Hyunchan Lee:1 Jihyun Noh:1 
  • 1:Department of Science Education, Dankook University, Yongin-si, Gyeonggi-do, Korea 

Nicotine, the addictive component of tobacco, presents a complex motivational profile capable of producing both highly reinforcing and aversive effects. To develop the nicotine aversion as a big advantage for treatment strategy of addiction, we here demonstrate new insights into the medial habenula as a key regulator for nicotine aversion. To determine the role of repeated nicotine exposure on its aversive properties, we performed a nicotine preference test using a free two-bottle choice consumption paradigm. We found a significant increase of nicotine intake preference in rats injected by repeated nicotine. Next, using an extracellular recording of medial habenular slices, we investigated the effects of repeated nicotine exposure on the electrical activity of medial habenular neurons and compared the activities between the rats injected by repeated nicotine and by saline. The treatment of nicotine dramatically increased the frequency of spontaneous spike activity in the medial habenula of naïve rat. Remarkably, in repeated nicotine-injected rats, we found the reduction of nicotine-induced spontaneous spike frequency, such that these neurons display significantly minimized basal activity and reduced spontaneous activity upon re-exposure to nicotine. These results demonstrate a functional switch in the activity of medial habenula by nicotine administration in the early phase versus repeated phases of nicotine exposure and suggest that nicotine-induced medial habenular activity determines the trigger for an inhibitory motivational signal that acts to limit nicotine consumption.

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