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Olfaction, Taste, Chemical Senses

開催日 2014/9/13
時間 11:00 - 12:00
会場 Poster / Exhibition(Event Hall B)

Function of Pou2f3/Skn-1a in the generation of solitary chemosensory cells in mice

  • P3-145
  • 山下 純平 / Junpei Yamashita:1 山口 達也 / Tatsuya Yamaguchi:1 應本 真 / Makoto Ohmoto:2 松本 一郎 / Ichiro Matsumoto:2 廣田 順二 / Junji Hirota:1,3 
  • 1:東京工業大学大学院 生命理工学研究科 生物プロセス専攻 / Dept. of Bioeng., Grad. Sch. of Biosci. and Biotech., Tokyo Inst. of Tech., Yokohama, Japan 2:モネル化学感覚研究所 / Monell Chemical Senses Center, Philadelphia, U. S. A. 3:東京工業大学大学院 バイオ研究基盤支援総合センター / Center for Biological Resources and Informatics, Tokyo Institute of Technology, Yokohama, Japan 

Solitary chemosensory cells (SCCs) are found in the upper airways in mammal. SCCs in the nasal respiratory epithelium detect noxious substances such as bitter chemicals and acylhomoserine lactone quorum-sensing molecules and evokes protective reflexes, including reduction in breathing frequency. SCCs express bitter receptors (Tas2rs), sweet and umami receptor component (Tas1r3), gustducin (Ggust), phospholipase C-β2 (PLCβ2), and transient receptor potential channel M5 (TRPM5). Its molecular features is similar to one of bitter taste receptor cells.
The Skn-1a (also known as POU2f3) gene encodes two functionally distinct POU homeodomain proteins, Skn-1a and Skn-1i, that plays critical roles in the development of epidermis. Recent studies have reported that Pou2f3/Skn-1a is involved in the generation of sweet, umami, and bitter taste receptor cells.
Here we show that Pou2f3/Skn-1a is also necessary for functional differentiation of SCCs. We carried out histological and molecular biological analysis to examine whether marker genes for the SCCs are detected in the anterior nasal cavity of Skn-1a-deficient mice. The results showed that maker genes are not detected in the Skn-1a-deficient mice tissues and suggest that Skn-1a plays an important role in the generation of the SCCs.

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