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Circadian pacemaking beyond clock genes: Neural network-based coherent oscillation and adaptive phasing by the suprachiamatic nucleus

開催日 2014/9/11
時間 9:00 - 11:00
会場 Room F(302)
Chairperson(s) 本間 さと / Sato Honma (北海道大学大学院医学系研究科 時間医学講座 / Department of Physiol Chronomedicine, Hokkaido University Graduate School of Medicine, Japan)
土居 雅夫 / Masao Doi (京都大学大学院薬学研究科医薬創成情報科学専攻システムバイオロジー分野 / Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan)

Mathematical Model of Suprachiasmatic Nucleus: Mechanism of Jet Lag

  • S1-F-1-5
  • 郡 宏 / Hiroshi Kori:1 
  • 1:お茶の水女子大学 / Ochanomizu University, Japan 

Jet-lag symptoms arise from temporal mismatch between the internal circadian clock and external solar time. We know by experience that it takes about one week to recover from jet lag (i.e., reentrainment) after a long-distance trip. We recently reported in [1] that, in mice lacking the receptors of a certain neurotransmitter (KO mice), circadian rhythms of behavior and clock gene expression rhythms immediately reentrained to phase-shifted light-dark (LD) cycles. Still, the internal clock of such mice works normally under standard conditions. Experiments indicate that oscillation of clock gene expression in wild type mice significantly weakens after a large phase shift, whereas that in KO mice is robust. To uncover the mechanism of jet lag symptoms, we constructed a multi-oscillator model of the circadian master clock (the suprachiasmatic nucleus, SCN). Based on previously reported experimental observations, our model consists of three functionally distinct regions. Our model nicely reproduced experimental results, providing an insight into the mechanism of jet lag. We will discuss implications of our model.

[1] Y. Yamaguchi, T. Suzuki, Y. Mizoro, H. Kori, K. Okada, Y. Chen, J.M. Fustin, F. Yamazaki, N. Mizuguchi, J. Zhang, X. Dong, G. Tsujimoto, Y. Okuno, M. Doi, H. Okamura: Mice Genetically Deficient in Vasopressin V1a and V1b Receptors Are Resistant to Jet Lag, Science 342, pp. 85-90 (2013)

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