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Chromatin (Epigenetic) regulation of neuronal development

開催日 2014/9/12
時間 9:00 - 11:00
会場 Room A(Main Hall)
Chairperson(s) 後藤 由季子 / Yukiko Gotoh (東京大学大学院薬学系研究科 / Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan)
内匠 透 / Toru Takumi (理化学研究所 脳科学総合研究センター / RIKEN Brain Science Institute, Japan)

Signaling networks that regulate synapse development and cognitive function

  • S2-A-1-5
  • Michael Greenberg:1 
  • 1:Harvard Medical School, USA 

Our interactions with the outside world trigger changes at synapses that are critical for proper brain development and higher cognitive function. Research in the Greenberg laboratory has focused on the identification of a genetic program that is activated by neuronal activity, the mechanisms of signal transduction that carry the neuronal activity-dependent signal from the membrane to the nucleus, and the identification of regulators of this experience-dependent process that affect synapse development and plasticity. Our recent studies using global screening techniques have identified activity-dependent genes that control 1) the complexity of the dendritic arbor, 2) the formation and maturation of excitatory and inhibitory synapses, 3) the composition of protein complexes at the pre- and post-synaptic sites, and 4) the production and secretion of neuropeptides that control neural circuit development. These activity-regulated processes are critical for normal brain development and function, and defects in the activity-dependent gene program contribute to disorders of human cognition such as Rett Syndrome (RTT) and Angelman Syndrome (AS), two neurological disorders associated with syndromic autism. Understanding how the neuronal activity-dependent gene program functions may provide insight into how the dysregulation of this process leads to neurological diseases and, ultimately, may suggest therapies for treatment of disorders of cognitive function.

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