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演題詳細

Symposium

大脳における記憶痕跡とタグ
Memory traces and tags in the brain

開催日 2014/9/11
時間 9:00 - 11:00
会場 Room B(501)
Chairperson(s) 奥野 浩行 / Hiroyuki Okuno (京都大学大学院 医学研究科 メディカルイノベーションセンター / Medical Innovation Center, Kyoto University Graduate School of Medicine, Japan)
尾藤 晴彦 / Haruhiko Bito (東京大学大学院 医学系研究科 神経生化学分野 / Department of Neurochemistry, The University of Tokyo Graduate School of Medicine, Japan)


Adult born hippocampal neurons and their role in hippocampal information processing

  • S1-B-1-2
  • Victor Ramirez-Amaya:1 Paola Crist Bello Medina:2 
  • 1:Facultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Mexico / Facultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Mexico 2:Departamento de Neurobiología Conductual y Cognitiva, Instituto de Neurobiología, UNAM, Mexico / Departamento de Neurobiología Conductual y Cognitiva, Instituto de Neurobiología, UNAM, Mexico 

Adult born granular neurons functionally integrate into the hippocampal network developing a specific response to spatial exploration when mature. This specific response to spatial exploration appears about 30 days after the neurons were born. This functional integration of adult born neurons into the behavioral relevant network resembles their functional and anatomical maturation process observed during the critical time for their survival, which occurs in the first 6 weeks after cell division. By comparing the recruitment probability of adult born neurons at some time points after their birth and including the different neurogenesis rates throughout the animal's life span, we developed a mathematical model suggesting that the contribution of adult born neurons to spatial information processing is highly relevant particularly at early adulthood. This model was partially confirmed by a study done in young and old rats, where we observed that even-though the rate of neurogenesis is significantly reduced in old rats, the likelihood of a mature (4 months old) new born neuron to be recruited by spatial exploration is the same between old and young animals. Finally, recent experimental evidence indicated that adult born neurons are preferentially recruited into circuits that process information about familiar objects presented shortly after learning, and that the recruitment probability of new neurons into familiar object representations is negatively correlated with the behavioral efficiency of the animal. Moreover, we had obtained evidence that spatial and object information processing recruits different new neuron populations, tagged at different periods of the animal's life. Altogether these results are contributing to develop our understanding of the role of adult born neurons in hippocampal information processing.

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