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Super-resolution microscopy: nano-scale spotlight for discovery of new principle in brain operation

開催日 2014/9/13
時間 9:00 - 11:00
会場 Room C(502)
Chairperson(s) 林 康紀 / Yasunori Hayashi (独立行政法人理化学研究所 脳科学総合研究センター / RIKEN Brain Science Institute, Japan)
坂内 博子 / Hiroko Bannai (名古屋大学大学院理学研究科生命理学専攻 / Department of Biological Science, Graduate School of Science, Nagoya University, Japan)

Molecular dynamic at synapses: toward chemistry in cellulo

  • S3-C-1-3
  • Antoine Triller:1 
  • 1:École Normale Supérieure, Paris, France 

Molecular dynamic at synapses: toward chemistry in cellulo

Antoine Triller
Institute for Biology (IBENS)
Ecole Normale Supérieure Paris

The variability of the postsynaptic response following a single action potential arises from two sources: the neurotransmitter release is probabilistic, and the postsynaptic response to neurotransmitter release has variable timing and amplitude. At individual synapses, the number of molecules of a given type that are involved in these processes is small enough that the stochastic (random) properties of molecular events cannot be neglected. How the stochasticity of molecular processes contributes to the variability of synaptic transmission, its sensitivity and its robustness to molecular fluctuations has important implications for our understanding of the mechanistic basis of synaptic transmission and of synaptic plasticity. Using single particle tracking and super-resolution imaging, we will address the issue of postsynaptic receptors dynamic, their interactions with scaffolding protein and regulations implicated in synaptic plasticity. Combination of single particle tracking and super-resolution methods, open access to molecular counting and energy involved in receptor-scaffold interactions as well as on and off rate of molecular interactions. Thus beyond super-resolution methods is chemistry "in cellulo" accounting for the regulation of receptor number and consecutively that of synaptic strength

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