• Top page
  • Timetable
  • Per session
  • Per presentation
  • How to
  • Meeting Planner



Challenges of imaging functional architecture of large-scale network

開催日 2014/9/11
時間 17:00 - 19:00
会場 Room F(302)
Chairperson(s) 定藤 規弘 / Norihiro Sadato (自然科学研究機構 生理学研究所 大脳皮質機能研究系 / Department of Cerebral Research, National Institute for Physiological Sciences, Japan)
林 拓也 / Takuya Hayashi (理化学研究所 ライフサイエンス技術基盤研究センター / Functional Architecture Imaging Unit, RIKEN Center for Life Science Technologies, Japan)

The relationship between intrinsic functional connectivity and structural connectivity: importance of large scale network interactions

  • S1-F-3-3
  • Jill O'reilly:1 Paula L Croxson:2 Mark G Baxter:2 
  • 1:Oxford Universityn UK 2:Ichan School of Medicine, Mount Sinai Medical School, New York, USA 

In the absence of external stimuli or task demands, correlations in spontaneous brain activity (functional connectivity) reflect patterns of anatomical connectivity. Hence resting state functional connectivity has been used as a proxy measure for structural connectivity, and as a biomarker for brain changes in disease. To relate changes in functional connectivity to physiological changes in the brain, it is important to understand how correlations in functional connectivity depend on the physical integrity of brain tissue. Intriguingly, patient data suggest that white matter damage does not always correlate with decreases in functional connectivity. To investigate this causal relationship, we measured how functional connectivity changed in monkeys after disconnection of white matter tracts (specifically, disconnection of the corpus callosum, with or without section of the anterior commissure). We found that forebrain commissurotomy severely reduced inter-hemispheric functional connectivity, but surprisingly, this effect was greatly mitigated if the anterior commissure was left intact. Furthermore, intact structural connections increased their functional connectivity in line with the hypothesis that the inputs to each node are normalized. We conclude that functional connectivity is likely driven by cortico-cortical white matter connections, but with complex network interactions such that a near-normal pattern of functional connectivity can be maintained by just a few, indirect structural connections. These surprising results highlight the importance of network-level interactions in functional connectivity, and may cast light on various paradoxical findings concerning changes in functional connectivity in disease states.

Copyright © Neuroscience2014. All Right Reserved.