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Plenary Lectures

開催日 2014/9/11
時間 13:00 - 14:00
会場 Room A(Main Hall)
Chairperson(s) 萩原 正敏 / Masatoshi Hagiwara (京都大学大学院医学研究科 形態形成機構学 / Department of Anatomy and Developmental Biology, Graduate School of Medicine, Kyoto University)

Epigenetics, neuronal metabolism and the circadian clock

  • PL-1
  • Paolo Sassone-Corsi:1 
  • 1:Department of Biological Chemistry, University of California, Irvine, USA 

Experimental and epidemiological evidence reveal the profound influence that industrialized modern society has imposed on human social habits and physiology during the past 50 years. This drastic change in lifestyle is thought to be one of the main causes of modern diseases including obesity, type 2 diabetes, mental illness such as depression, sleep disorders, and certain types of cancer. These disorders have been associated with disruption of the circadian clock, an intrinsic time-keeper molecular system present in virtually all cells and tissues. The circadian clock is a key element in homeostatic regulation by controlling a large array of genes implicated in cellular metabolism. Importantly, intimate links between epigenetic regulation and the circadian clock exist and are likely to prominently contribute to the plasticity of the response to the environment. I will present some experimental and epidemiological evidence showing how environmental factors such as stress, drugs of abuse and changes in circadian habits, interact through different brain areas to modulate the endogenous clock. Furthermore, I will point out the pivotal role of the deacetylase silent mating-type information regulation 2 homolog 1 (SIRT1) as a molecular effector of the environment in shaping the circadian epigenetic landscape.

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