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演題詳細

Symposium

日本-中国神経科学学会合同シンポジウム:Neuronal signaling for development and plasticity
Joint Symposium of the Japan Neuroscience Society and the Chinese Society for Neuroscience:Neuronal signaling for development and plasticity

開催日 2014/9/12
時間 17:10 - 19:10
会場 Room C(502)
Chairperson(s) 上口 裕之 / Hiroyuki Kamiguchi (理研BSI神経成長機構 / RIKEN Brain Science Institute, Japan)


Roles of PICK1-ICA69 BAR Domain Complexes in Protein Trafficking

  • S2-C-3-2
  • Jun Xia:1 
  • 1:Hong Kong University of Science and Technology, China 

Roles of PICK1-ICA69 BAR Domain Complexes in Protein Trafficking

Jun Xia

Division of Life Science, Hong Kong University of Science and Technology
Clear Water Bay, Kowloon, Hong Kong, China

Mammalian cells are divided by elaborate membrane compartments. Proteins are transported between different compartments via trafficking vesicles. Protein trafficking is tightly regulated to ensure proper function of different proteins. We identified PICK1 (Protein interacting with C Kinase 1), a peripheral membrane protein with a PDZ domain and a BAR domain, as an important protein trafficking regulator. The PDZ domain of PICK1 binds to a number of membrane proteins while the BAR domain of PICK1 binds to liposome and couple membrane proteins to trafficking vesicles. In addition, the BAR domain of PICK1 forms tight heteromeric BAR domain complex with ICA69 (Islet Cell Autoantigen 69kd), another BAR domain containing protein. The switch from heteromeric PICK1-ICA69 to homomeric PICK1-PICK1 BAR domain complex provides an important mechanism for vesicle sorting and refinement. In brain, PICK1 interacts and regulates the trafficking of AMPA type glutamate receptor and this regulation was found to be important for synaptic plasticity, a well studied cellular model of learning and memory.

Supported by Research Grants Council of Hong Kong SAR, China

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