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Chromatin (Epigenetic) regulation of neuronal development

開催日 2014/9/12
時間 9:00 - 11:00
会場 Room A(Main Hall)
Chairperson(s) 後藤 由季子 / Yukiko Gotoh (東京大学大学院薬学系研究科 / Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan)
内匠 透 / Toru Takumi (理化学研究所 脳科学総合研究センター / RIKEN Brain Science Institute, Japan)

The anti-apoptotic factor bclw promotes viability of axons within functional circuits

  • S2-A-1-4
  • Rosalind Segal:1 Maria Pazyra-Murphy:1 Katharina Cosker:1 
  • 1:Dana Farber Cancer Institute, USA 

Axons provide the essential long-range connections that establish and maintain complex brain circuitry. However, the mechanisms that regulate axonal viability during development and throughout life are not well understood. We report that a distinctive anti-apoptotic factor, bclw, is highly enriched within long-range axons. We show that neurotrophin stimulation of nerve terminals promotes transcription of bclw, and that the newly transcribed mRNA is immediately transported to the axons that have been exposed to neurotrophins. Neurotrophins may additionally regulate local translation of this anti-apoptotic factor in the axons. Regulation of bclw and other anti-apoptotic factors at the levels of transcription, transport and translation provides a mechanism whereby sustained neurotrophin stimulation can be spatially selective and be integrated over time, so that axonal survival is restricted to neurons connected within a stable circuit.

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