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日本-韓国神経科学学会合同シンポジウム:Molecular Mechanisms underlying Parkinson Disease
Joint Symposium of the Japan Neuroscience Society and the Korean Society of Brain and Neuroscience:Molecular Mechanisms underlying Parkinson Disease

開催日 2014/9/12
時間 9:00 - 11:00
会場 Room C(502)
Chairperson(s) 望月 秀樹 / Hideki Mochizuki (大阪大学医学系研究科神経内科学 / Department of Neurology, Osaka University Graduate School of Medicine, Japan)
Young Jun Oh (Department of Systems Biology, Yonsei University College of Life Science and Biotechnology, Korea)

Function of transient receptor potential vanilloid 1 in Parkinson’s disease

  • S2-C-1-3
  • Byung Kwan Jin:1 
  • 1:Kyung Hee University ,Korea 

Transient receptor potential vanilloid 1 (TRPV1) is involved in pain perception and highly expressed in sensory neurons. TRPV1 is also present in the brain and has been implicated in L-dopa induced locomotion and dyskinesia, in the SN with a potential relationship to Parkinson’s disease (PD), in which the degeneration of dopamine neurons in the SN pars compacta (SNpc) plays a prominent causative role. Here we report that activation of TRPV1 prevents degeneration of dopamine neurons with behavioral recovery in animal models of Parkinson’s disease. Our results suggest that TRPV1 activation might be a novel therapeutic target and beneficial for the treatment of PD

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