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Axonal Regeneration and Tissue Repair

開催日 2014/9/13
時間 14:00 - 15:00
会場 Poster / Exhibition(Event Hall B)

Roles of LOTUS, an endogenous Nogo receptor antagonist, in nerve regeneration after spinal cord injury

  • P3-078
  • 廣川 智子 / Tomoko Hirokawa:1 榊原 裕介 / Yusuke Sakakibara:2 栗原 裕司 / Yuji Kurihara:1 池谷 真澄 / Masumi Iketani:1 五嶋 良郎 / Yoshio Goshima:2 竹居 光太郎 / Kohtaro Takei:1 
  • 1:横浜市大院・生命医・生体機能医 / Mol. Med. Biosci. Lab., Grad. Sch. of Med. Life Sci., Yokohama City Univ., Yokohama, Japan 2:横浜市大院・医・分子薬理神経 / Dept Mol. Pharmacol. & Neurobiol., Grad. Sch. of Med., Yokohama City Univ., Yokohama, Japan 

After spinal cord injury (SCI), primates, such as humans, hardly recover the locomotor function, but rodents, such as mice and rats, show a partial recovery of the locomotor function. However, the factors associated with this partial improvement of nerve regeneration after SCI in rodents remain completely unknown. It has been considered that axon growth inhibitors such as Nogo proteins, myelin-associated glycoprotein, oligodendrocyte myelin glycoprotein and B lymphocyte stimulator cause the limitation of nerve regeneration. Nogo receptor-1 (NgR1) is a common receptor for these four axonal growth inhibitors. We previously identified lateral olfactory tract usher substance (LOTUS) serving as an endogenous NgR1 antagonist. We found that lotus-deficient mice showed delayed locomotor functional recovery after SCI with down-regulation of LOTUS expression in injured site compared with the wild type mice. We therefore speculate that down-regulation of LOTUS might be one of the factor for limitation of the locomotor recovery. To examine effects of overexpression of endogenous LOTUS on the partial recovery of the locomotor function after SCI in rodents, we generated the animal model of SCI in lotus-transgenic mice. We found clearly that recovery of the locomotor function was promoted in lotus-transgenic mice compared with the wild type mice. These results suggest that LOTUS may contribute to promotion of functional recovery after SCI.

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