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Optical Methods

開催日 2014/9/12
時間 11:00 - 12:00
会場 Poster / Exhibition(Event Hall B)

Brain functional imaging with an implantable CMOS imaging device for using in a behavior experiment

  • P2-397
  • 春田 牧人 / Makito Haruta:1 須永 圭紀 / Yoshinori Sunaga:1 山口 貴大 / Takahiro Yamaguchi:1 竹原 浩成 / Hironari Takehara:1 野田 俊彦 / Toshihiko Noda:1 笹川 清隆 / Kiyotaka Sasagawa:1 徳田 崇 / Takashi Tokuda:1 太田 淳 / Jun Ohta:1 
  • 1:奈良先端科学技術大学院大学 / Nara Institute of Science and Technology 

In the neuroscience study, it is important to measure brain functions in a behavioral experiment for understanding a behavioral control of an animal. However, measuring brain function during a behavior experiment is difficult. In order to solve the problem, we have developed a novel device that can be implanted into a small animal's head. This device is made with a CMOS image sensor which makes up the main part of a digital camera.
In this study, we develop a small implantable CMOS imaging device and successfully measured blood flow velocity and intrinsic signals in a rat-brain surface. For the device, we designed a custom image sensor using CMOS integrated circuit technology. This enables to reduce the size and weight of the device significantly [1,2]. The sensor is placed on a flexible polyimide substrate. Six green-LEDs and five red-LEDs are located around the sensor as light sources. This device has a very compact shape with dimension of 3.3 mm Χ 5.3 mm Χ 0.35 mm. We demonstrated brain functional imaging with our device with an adult rat. We anesthetized the rat and placed the device directly on the brain surface. In these experiments, our device used two-light sources. The green light (λ= 535 nm) is used for measuring blood flow velocity. This wavelength is one of absorption spectral peaks of hemoglobin in the blood [3]. We have successfully estimated blood flow velocity on the brain surface. Red light (λ= 630 nm) is used for measuring intrinsic signal in the brain. At this wavelength, intrinsic signals arise from oxyhemoglobin (HbO2) in the brain, because hemoglobin (Hb) absorption is higher than HbO2 absorption. We have successfully measured the responses of the primary sensory cortex from sensory stimuli.
We successfully obtained blood flow velocity and measured intrinsic signals by using our device. In the next work, we will try observation of brain functions related to behavior with our implantable CMOS imaging device.
[1] M. Haruta et al., Jpn. J. Appl. Phys. 53 (2014) 04EL05.
[2] A. Tagawa et al., Jpn. J. Appl. Phys. 49 (2010) 01AG02.
[3] Oregon Medical Laser Center [http://omlc.ogi.edu/].

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