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Ion Channels and Excitable Membranes

開催日 2014/9/12
時間 14:00 - 15:00
会場 Poster / Exhibition(Event Hall B)

Ryanodine Receptor Dependent Firing Prolongation in the Striatum

  • P2-012
  • 太田 宏之 / Hiroyuki Ohta:1 田村 吏沙 / Risa Tamura:1 田代 晃正 / Akimasa Tashiro:1 守本 祐司 / Yuji Morimoto:1,2 西田 育弘 / Yasuhiro Nishida:1 
  • 1:防衛医大生理 / Dept Physiol, National Defense Medical College, Saitama, Japan 2:防衛医大分子生体 / Dept Integrative Phys, National Defense Medical College, Saitama, Japan 

To characterize a property of firing prolongation by repetitive input cycles, and a residual effect after a decasecond intermission, we studied striatal neurons in slice and confirmed in vivo. The striatum neurons showed a residual firing response of increasing duration when exposed to repetitive optogenetic photostimulation. The prolonged firing persisted after a 20 sec intermission. Repetitive photostimulation to patch-clamped neuron induced residual depolarization with a decay of 8.6-sec half-life time and firing prolongation, but current injection to the soma did not. Ryanodine receptor antagonists significantly decreased development of prolongation. On the other hand, a ryanodine receptor agonist increased the firing development. Local anesthetics, including procaine, and lidocaine canceled the residual firing. These phenomena indicate that striatal neurons hold their internal state in second-order timescale through ryanodine receptor mediated calcium release to count inputs cumulatively.

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