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Olfaction, Taste, Chemical Senses

開催日 2014/9/12
時間 14:00 - 15:00
会場 Poster / Exhibition(Event Hall B)

嗅覚認識研究への7 Tesla fMRIの適用
Applying 7 Tesla fMRI to an odor recognition study

  • P2-164
  • 深見 秀之 / Hideyuki Fukami:1 堀江 沙和 / SAWA HORIE:1,2 樋口 さとみ / SATOMI HIGUCHI:3 佐々木 真理 / MAKOTO SASAKI:3 佐原 資謹 / YOSHINORI SAHARA:1 
  • 1:岩手医大・生理 / Dept Physiol, Iwate Medical Univ, Iwate, Japan 2:岩手医大・腫瘍生物学研究部門 / Dept Tumor Biol, Inst Biomed Sci, Iwate Medical Univ, Iwate, Japan 3:岩手医大・超高磁場MRI診断・病態研究部門 / Div Ultrahigh Field MRI, Inst Biomed Sci, Iwate Medical Univ, Iwate, Japan 

Functional magnetic resonance imaging (fMRI) has been used to investigate odor-induced brain activation in humans. Piriform cortex forms a main part of the primary olfactory cortex, yet the role in olfaction remain unclear. Several factors attributed to this are: 1) BOLD-signal changes evoked by olfactory stimuli are small, 2) brain regions involved in olfaction tend to be susceptible to spatial distortion and signal and 3) inter-individual difference of the piriform cortex is prominent. In order to investigate odorant induced olfactory cortex BOLD signal activation, we utilized ultra high field MRI expecting for increasing BOLD-signal strength. A 7T MRI (GE Discovery MR950 system) echo-planar imaging (EPI) pulse sequence with a short echo time (TE) was chosen to minimize high field related susceptibility artifacts such as geometric distortion, and signal dropout in the piriform cortex. Spatial normalization of anatomical and functional images was performed with a VBM8 toolbox. This approach apparently reduced molphological inter-individual variability in the piriform cortex. As a result, we can detect BOLD-signal activation in the piriform cortex, amygdalae, orbitofrontal cortex and hippocampus in response to different (isovaleric acid, peppermint and coffee odors) odors. The spatial extent of BOLD signal activation in the piriform cortex varied for each odorant, with a spatial overlap. These results demonstrate that ultra high field fMRI with image normalization using VBM8 can be a viable approach for investigating olfactory stimulation.

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