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Visual System

開催日 2014/9/11
時間 16:00 - 17:00
会場 Poster / Exhibition(Event Hall B)

Light-evoked cooperative spike discharges of retinal ganglion cells during eye movements

  • P1-168
  • 松本 彰弘 / Akihiro Matsumoto:1 立花 政夫 / Masao Tachibana:1 
  • 1:東京大院人文社会行動文化・心理 / Dept Psychol, Univ of Tokyo, Tokyo, Japan 

Our visually perceived world is stable, irrespective of the incessant motions of the retinal image. Accumulating evidence indicates that the central nervous system may play a key role for stabilization of the visual world. However, it is not evident how the retina processes visual information during eye movements. Furthermore, it is not clear whether multiple subtypes of retinal ganglion cells (GCs) send visual information independently or cooperatively. In this study, by applying the multi-electrode array to the retina isolated from the goldfish, we recorded spike discharges of GCs evoked by dynamic light stimulus mimicking the retinal image during eye movements. GCs were physiologically classified into six subtypes (Fast/Medium/Slow, transient/sustained) based on the temporal properties of the receptive field estimated by the reverse correlation method. Nearby Fast-transient (Ft) GCs fired synchronously and anticipatory when the target stimulus rapidly approached their receptive fields together with the background with random dots. Under this stimulus condition, functional connectivity was established among the Ft GCs and some specific GC subtypes. The functional connectivity among nearby GCs changed in strength depending on the light stimulus pattern. It is commonly accepted that the timing of light-evoked spikes is jittered from trial to trial. However, as the time axis in each trial was aligned to the spike timing of the Ft GCs, the spike jitter decreased significantly in some specific GC subtypes whereas that of the other subtypes did not change. In other words, the Ft GCs fired anticipatory to rapidly moving stimulus, and then the nearby specific GC subtypes fired after a constant time lag. These results suggest that during eye movements the Ft GCs may functionally connect with specific GC subtypes, and these specific GC subtypes may send visual information cooperatively to the brain. It is likely that the Ft GCs may work as a "trigger-pulse generator" for parallel information processing. The other GC subtypes may send visual information independently of the Ft GC activity.

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