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Reward and Decision Making

開催日 2014/9/11
時間 11:00 - 12:00
会場 Poster / Exhibition(Event Hall B)

Neural representation of task-level and motor information in the cortico-basal ganglia loops

  • P1-235
  • 吉澤 知彦 / Tomohiko Yoshizawa:1,2 伊藤 真 / Makoto Ito:2 銅谷 賢治 / Kenji Doya:1,2 
  • 1:奈良先端科学技術大学院大学 / NAIST, Nara, Japan 2:沖縄科学技術大学院大学 / Neural Computation Unit, OIST, Okinawa, Japan 

The cortico-basal ganglia loops are known for its role in both physical movement and reward-based decision making. The previous studies on decision making reported that the cortico-basal ganglia loops process task-level information, such as selected actions or reward outcome. However, it is possible that the neural activities also encode motor parameters, such as waking speed, acceleration or moving directions.
In this study, to investigate neural representations of the task and motor information in the cortico-basal ganglia loops including prefrontal cortex and motor cortex, we recorded the neuronal activities from the dorsomedial striatum (DMS), the prelimbic cortex (PL; a dorsal part of the prefrontal cortex), and the primary motor cortex (M1) of rats during a choice task. Rats performed a task in a chamber with three nose poke holes, a pellet dish on the opposite wall, and a 3D motion tracking system. We attached infrared reflective markers on the rat's head, back, and tail. Rats were required to select either the left or right hole after the offset of the cue tone by nose poking and then received a reward stochastically. To test neuronal correlation with task-level and motor information, we applied a stepwise multiple linear regression analysis.
We recorded the activities of 101 DMS, 36 PL, and 113 M1 neurons from 2 rats. The proportions of neurons in DMS, PL, and M1 correlated with selected actions were 55%, 47%, and 67%, respectively. The proportions were 87%, 75%, and 89% for moving speed and 76%, 72%, and 90% for egocentric moving directions. The proportions of M1 neurons correlated with selected actions, moving speed, acceleration, and directions were significantly larger than PL (χ2-test, α = 0.01).
These results suggest that the cortico-basal ganglia loops including prefrontal cortex and motor cortex process not only task-level information but also motor information.

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